Clin Orthop Surg.  2014 Dec;6(4):439-442. 10.4055/cios.2014.6.4.439.

The Analysis of Treatment of Aggressive Fibromatosis Using Oral Methotrexate Chemotherapy

Affiliations
  • 1Department of Orthopaedic Surgery, Kosin University Gospel Hospital, Kosin University College of Medicine, Busan, Korea. shchung@Kosin.ac.kr

Abstract

BACKGROUND
Aggressive fibromatosis is a rare but invasive tumor infiltrating widely between fascia and muscle fibers. It has a high tendency to be locally recurrent despite complete resection. Effectiveness of adjuvant treatment for aggressive fibromatosis including radiotherapy, pharmacological agents, hormonal treatments, and chemotherapy have been previously reported. The purpose of this article was to collect and analyze all information regarding the effectiveness and side effects of oral methotrexate in aggressive fibromatosis.
METHODS
From 2005 to 2011, eleven patients with aggressive fibromatosis treated with oral methotrexate at our institution were analyzed in this study. Oral methotrexate was administered once per week at 10 mg per week. Authors collected information about effectiveness concerning cases of local recurrence and metastasis.
RESULTS
Eleven patients had remission, two patients had local recurrence. Fatal complications or toxicity were not observed.
CONCLUSIONS
Oral methotrexate given at this dose and schedule was considered as a useful treatment in primary inoperable fibromatosis and recurrent fibromatosis.

Keyword

Aggressive fibromatosis; Oral methotrexate

MeSH Terms

Administration, Oral
Adolescent
Adult
Aged
Antimetabolites, Antineoplastic/*administration & dosage
Child
Female
Fibromatosis, Aggressive/*drug therapy/surgery
Humans
Male
Methotrexate/*administration & dosage
Middle Aged
Neoplasm Recurrence, Local/*drug therapy/surgery
Retrospective Studies
Young Adult
Antimetabolites, Antineoplastic
Methotrexate
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