Korean J Gastroenterol.  2010 Apr;55(4):237-244. 10.4166/kjg.2010.55.4.237.

Analysis of Risk Factors for Low Bone Mineral Density in Patients with Inflammatory Bowel Disease

• Park JJ
• Jung SA
• Noh YW
• Kang MJ
• Jung JM
• Kim SE
• Jung HK
• Shim KN
• Kim TH
• Yoo K
• Moon IH
• Hong YS

• KMID: 1792774
• DOI: http://doi.org/10.4166/kjg.2010.55.4.237

Abstract

BACKGROUND/AIMS: Several clinical risk factors for low bone mineral density (BMD) in the patients with inflammatory bowel disease (IBD) have been suggested. However, its prevalence and pathophysiology in Korean population have not been fully studied. The aim of this study was to investigate the prevalence and risk factors for low BMD in Korean IBD patient.
METHODS
BMD of the lumbar spine and femur was evaluated using dual-energy X-ray absorptiometry in 30 patients with IBD. Biochemical parameters of bone metabolism, such as serum calcium, phosphorus, osteocalcin, and deoxypyridinoline were measured. The associations between low BMD and clinical parameters such as disease duration, disease activity, drug history, body mass index (BMI), and others were evaluated retrospectively using medical records.
RESULTS
Low BMD at the lumbar spine or femur was observed in 63.3% of the patients, and there was no significant difference between the patients with Crohn's disease and ulcerative colitis. Clinical and biochemical parameters were irrelevant to BMD. In the patients without glucocorticoid treatment prior to BMD measurement, already 50.0% of patients had low BMD.
CONCLUSIONS
Low BMD is a common feature in Korean IBD patients, even those who do not use glucocorticoid. The multiple factors may be involved in the pathogenesis of low BMD. Therefore, BMD should be examined in all IBD patients, irrespective of glucocorticoid treatment.

Keyword

Inflammatory bowel disease; Bone mineral density; Crohn's disease; Ulcerative colitis

MeSH Terms

Absorptiometry, Photon
Adolescent
Adult
Amino Acids/blood
Body Mass Index
*Bone Density
Calcium/blood
Colitis, Ulcerative/diagnosis/radiography
Crohn Disease/diagnosis/radiography
Female
Glucocorticoids/therapeutic use
Humans
Inflammatory Bowel Diseases/diagnosis/drug therapy/*radiography
Male
Middle Aged
Osteocalcin/blood
Phosphorus/blood
Prevalence
Retrospective Studies
Risk Factors

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