Korean J Ophthalmol.  2014 Feb;28(1):12-18. 10.3341/kjo.2014.28.1.12.

The Effect of 0.02% Mitomycin C Injection into the Hair Follicle with Radiofrequency Ablation in Trichiasis Patients

• Kim GN
• Yoo WS
• Kim SJ
• Han YS
• Chung IY
• Park JM
• Yoo JM
• Seo SW

• KMID: 1792089
• DOI: http://doi.org/10.3341/kjo.2014.28.1.12

Abstract

PURPOSE
To investigate the inhibitory effect of 0.02% mitomycin C on eyelash regrowth when injected to the eyelash hair follicle immediately after radiofrequency ablation.
METHODS
We prospectively included 21 trichiasis patients from June 2011 to October 2012. Twenty eyes of 14 patients were treated with 0.02% mitomycin C to the hair follicle immediately after radiofrequency ablation in group 1, while radiofrequency ablation only was conducted in ten eyes of seven patients in group 2. Recurrences and complications were evaluated until six months after treatment.
RESULTS
One hundred sixteen eyelashes of 20 eyes in group 1 underwent treatment, and 19 (16.4%) eyelashes recurred. Eighty-four eyelashes of ten eyes in group 2 underwent treatment, and 51 (60.7%) eyelashes recurred. No patients developed any complications related to mitomycin C.
CONCLUSIONS
Application of 0.02% mitomycin C in conjunction with radiofrequency ablation may help to improve the success rate of radiofrequency ablation treatment in trichiasis patients.

Keyword

Ablation techniques; Mitomycin; Trichiasis

MeSH Terms

Antibiotics, Antineoplastic/administration & dosage
Catheter Ablation/*methods
Dose-Response Relationship, Drug
Eyelashes
Female
Follow-Up Studies
Hair Follicle
Humans
Injections
Male
Middle Aged
Mitomycin/*administration & dosage
Prospective Studies
Treatment Outcome
Trichiasis/diagnosis/*therapy
Antibiotics, Antineoplastic
Mitomycin

Figure

• 

  Fig. 1 (A) After flipping the lid margin to the far side of the eyeball, a sterilized epilation needle connected to a 3.8-MHz Ellman Surgitron was inserted into the root of the eyelashes to a depth of 2 to 3 mm in the cut and coagulation mode (power = 3) in order to easily remove eyelashes, and follicles were cauterized. (B) After that, 0.1 mL 0.02% mitomycin C was injected by attaching a 27-gauge cannula to a 1-mL syringe in eyelash-removed follicles and left for two minutes after radiofrequency ablation.

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  Fig. 2 (A) An image of the preoperative eyelashes (black arrows). (B) An image of eyelashes six months after the operation.

• 

  Fig. 3 Optical microscopic findings revealed structural damage in all four follicles. Thickened follicle epithelium and sebaceous glands were observed after the regeneration process. (A-C) The dermal papillae were destroyed and not found in three hair follicles. (D) However, dermal papillae remained in the remaining follicle, and growth of the hair shaft was observed (H&E, ×100).

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  Fig. 4 Patient in group 1. (A) Image of the preoperative eyelid. (B) There was no deformity or scarring in the eyelid at six postoperative months. Patient in group 2. (C) Image of the preoperative eyelid. (D) Notching in the eyelid at six postoperative months (black arrow).

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