Korean J Med Mycol.
2013 Dec;18(4):111-116.
Primary Cutaneous Cryptococcosis in a Patient with Pulmonary Tuberculosis
- Affiliations
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- 1Department of Dermatology, School of Medicine, Pusan National University, Korea. hcko@pusan.ac.kr
- 2Department of Dermatology, Pusan National University Yangsan Hospital; Dermatology, Korea.
Abstract
- Cutaneous manifestation due to Cryptococcus neoformans is mostly reported in cases of the secondary findings to hematogenous dissemination while the primary cutaneous cryptococcosis (PCC) is a very rare. PCC usually occurs in immunocompromised hosts such as AIDS, hematopoietic malignancies, transplant recipients, and chronic corticosteroid users. Primary cryptococcosis and tuberculosis co-infection has been rarely reported in Korean literature. We report a case of PCC in a 22-year-old male with pulmonary tuberculosis, who had asymptomatic erythematous plaque and papules on the right cheek for 3 months. Histopathological examination showed numerous encapsulated round spores in the dermis and the organism was identified as Cryptococcus neoformans on fungal culture. The lesion was successfully treated with oral fluconazole for 6 months, and pulmonary tuberculosis was resolved after anti-tuberculosis therapy for 9 months.
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