Korean J Med Mycol.  2013 Dec;18(4):111-116.

Primary Cutaneous Cryptococcosis in a Patient with Pulmonary Tuberculosis

Affiliations
  • 1Department of Dermatology, School of Medicine, Pusan National University, Korea. hcko@pusan.ac.kr
  • 2Department of Dermatology, Pusan National University Yangsan Hospital; Dermatology, Korea.

Abstract

Cutaneous manifestation due to Cryptococcus neoformans is mostly reported in cases of the secondary findings to hematogenous dissemination while the primary cutaneous cryptococcosis (PCC) is a very rare. PCC usually occurs in immunocompromised hosts such as AIDS, hematopoietic malignancies, transplant recipients, and chronic corticosteroid users. Primary cryptococcosis and tuberculosis co-infection has been rarely reported in Korean literature. We report a case of PCC in a 22-year-old male with pulmonary tuberculosis, who had asymptomatic erythematous plaque and papules on the right cheek for 3 months. Histopathological examination showed numerous encapsulated round spores in the dermis and the organism was identified as Cryptococcus neoformans on fungal culture. The lesion was successfully treated with oral fluconazole for 6 months, and pulmonary tuberculosis was resolved after anti-tuberculosis therapy for 9 months.

Keyword

Primary cutaneous cryptococcosis; Pulmonary tuberculosis; Co-infection

MeSH Terms

Cheek
Coinfection
Cryptococcosis*
Cryptococcus neoformans
Dermis
Fluconazole
Hematologic Neoplasms
Humans
Immunocompromised Host
Male
Spores
Transplantation
Tuberculosis
Tuberculosis, Pulmonary*
Young Adult
Fluconazole
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