Clin Mol Hepatol.  2014 Jun;20(2):204-207. 10.3350/cmh.2014.20.2.204.

Pure red-cell aplasia and autoimmune hemolytic anemia in a patient with acute hepatitis A

• Chang HJ
• Sinn DH
• Cho SG
• Oh TH
• Jeon TJ
• Shin WC
• Choi WC

• KMID: 1788570
• DOI: http://doi.org/10.3350/cmh.2014.20.2.204

Abstract

Pure red cell aplasia (PRCA) and autoimmune hemolytic anemia (AIHA) have rarely been reported as an extrahepatic manifestation of acute hepatitis A (AHA). We report herein a case of AHA complicated by both PRCA and AIHA. A 49-year-old female with a diagnosis of AHA presented with severe anemia (hemoglobin level, 6.9 g/dL) during her clinical course. A diagnostic workup revealed AIHA and PRCA as the cause of the anemia. The patient was treated with an initial transfusion and corticosteroid therapy. Her anemia and liver function test were completely recovered by 9 months after the initial presentation. We review the clinical features and therapeutic strategies for this rare case of extrahepatic manifestation of AHA.

Keyword

Hepatitis A; Pure red-cell aplasia; Autoimmune hemolytic anemia

MeSH Terms

Acute Disease
Adult
Anemia, Hemolytic, Autoimmune/*complications/*diagnosis/drug therapy
Antineoplastic Agents, Hormonal/therapeutic use
Bone Marrow/pathology
Female
Hepatitis A/*complications/*diagnosis
Humans
Male
Middle Aged
Prednisolone/therapeutic use
Red-Cell Aplasia, Pure/*complications/*diagnosis/drug therapy
Treatment Outcome
Young Adult
Antineoplastic Agents, Hormonal
Prednisolone