Blood Res.  2015 Mar;50(1):55-58. 10.5045/br.2015.50.1.55.

A case of pediatric ALL with t(16;21)(p11.2;q22) and FUS-ERG rearrangement

Affiliations
  • 1Servicio de Genetica. Hospital de Pediatria "Prof. Dr. J. P. Garrahan", Buenos Aires, Argentina. marielacocce@yahoo.com.ar
  • 2Servicio de Hemato-Oncologia. Hospital de Pediatria "Prof. Dr. J. P. Garrahan", Buenos Aires, Argentina.
  • 3Servicio de Inmunologia. Hospital de Pediatria "Prof. Dr. J. P. Garrahan", Buenos Aires, Argentina.

Abstract

No abstract available.


Figure

  • Fig. 1 Morphology of leukemic cells at diagnosis showing L1/L2 blasts.

  • Fig. 2 (A) Partial karyotype showing a reciprocal translocation between 16p11.2 and 21q22; (B) Sequencing analysis of the RT-PCR product identifying a fusion between exon 7 of FUS and exon 6 of ERG.


Reference

1. Huret JL. t(16;21)(p11;q22). Atlas Genet Cytogenet Oncol Haematol. 2005; 9:36–38.
2. Ichikawa H, Shimizu K, Hayashi Y, Ohki M. An RNA-binding protein gene, TLS/FUS, is fused to ERG in human myeloid leukemia with t(16;21) chromosomal translocation. Cancer Res. 1994; 54:2865–2868. PMID: 8187069.
3. Liu F, Gao L, Jing Y, et al. Detection and clinical significance of gene rearrangements in Chinese patients with adult acute lymphoblastic leukemia. Leuk Lymphoma. 2013; 54:1521–1526. PMID: 23210573.
4. Heller A, Loncarevic IF, Glaser M, et al. Breakpoint differentiation in chromosomal aberrations of hematological malignancies: Identification of 33 previously unrecorded breakpoints. Int J Oncol. 2004; 24:127–136. PMID: 14654949.
Article
5. Kanazawa T, Ogawa C, Taketani T, Taki T, Hayashi Y, Morikawa A. TLS/FUS-ERG fusion gene in acute lymphoblastic leukemia with t(16;21)(p11;q22) and monitoring of minimal residual disease. Leuk Lymphoma. 2005; 46:1833–1835. PMID: 16263589.
6. Oh SH, Park TS, Choi JR, et al. Two childhood cases of acute leukemia with t(16;21)(p11.2;q22): second case report of infantile acute lymphoblastic leukemia with unusual type of FUS-ERG chimeric transcript. Cancer Genet Cytogenet. 2010; 200:180–183. PMID: 20620604.
Article
7. van Dongen JJ, Macintyre EA, Gabert JA, et al. Standardized RT-PCR analysis of fusion gene transcripts from chromosome aberrations in acute leukemia for detection of minimal residual disease. Report of the BIOMED-1 Concerted Action: investigation of minimal residual disease in acute leukemia. Leukemia. 1999; 13:1901–1928. PMID: 10602411.
8. Kong XT, Ida K, Ichikawa H, et al. Consistent detection of TLS/FUS-ERG chimeric transcripts in acute myeloid leukemia with t(16;21)(p11;q22) and identification of a novel transcript. Blood. 1997; 90:1192–1199. PMID: 9242552.
9. Mitelman F, Johansson B, Mertens F. Mitelman Database of Chromosome Aberrations and Gene Fusions in Cancer. Bethesda, MD: National Cancer Institute;2013. Assessed May 20, 2014. at http://cgap.nci.nih.gov/Chromosomes/Mitelman.
Full Text Links
  • BR
Actions
Cited
CITED
export Copy
Close
Share
  • Twitter
  • Facebook
Similar articles
Copyright © 2024 by Korean Association of Medical Journal Editors. All rights reserved.     E-mail: koreamed@kamje.or.kr