J Korean Med Sci.  2008 Feb;23(1):35-40. 10.3346/jkms.2008.23.1.35.

Intima-Media Thickness and Pulse Wave Velocity in Hypertensive Adolescents

• Gil TY
• Sung CY
• Shim SS
• Hong YM

• KMID: 1786842
• DOI: http://doi.org/10.3346/jkms.2008.23.1.35

Abstract

Increased intima-media thickness (IMT) and pulse wave velocity (PWV) are noninvasive markers of early arterial wall alteration and are more widely used in adult clinical research. We investigated whether IMT and PWV are useful predictors of cardiovascular risk in hypertensive adolescents. Fifteen hypertensive adolescents (13-18 yr old, systolic BP > or = 140 mmHg, diastolic BP > or = 90 mmHg) and seventeen normotensive subjects were included. Height, weight, obesity index, body mass index (BMI), and fat distribution were obtained from each group. Serum lipid, insulin, vitamine B12, folate, renin, aldosterone, angiotensin-converting enzyme (ACE), and homocysteine levels were compared. The carotid IMT and PWV were measured. Arterial wall compliance and distensibility were calculated with the equation. High systolic blood pressure significantly correlated with height, weight, BMI, obesity index, arm circumference, fat mass, and fat distribution. Hypertensive adolescents had significantly greater cIMT (carotid intima-media thickness) and lower elastic properties such as cross-sectional compliance and distensibility of the carotid artery. The carotid IMT significantly correlated with brachial-ankle PWV. In conclusion, the measurement of carotid IMT and brachial-ankle PWV might be useful to predict the development of atherosclerosis in hypertensive adolescents.

Keyword

Carotid Intima-Media Thickness (cIMT); Pulse Wave Velocity (PWV); Hypertension; Atherosclerosis; Adolescent

MeSH Terms

Adolescent
Arteries/*pathology/physiopathology
Body Mass Index
Elasticity
Female
Humans
Hypertension/*pathology/physiopathology
Male
Tunica Intima/*pathology/physiopathology
Tunica Media/*pathology/physiopathology

Figure

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  Fig. 1 There was a significant linear correlation between common carotid artery IMT and RhbaPWV. The equation of slope is Y=7.658E-0.5X+6.434E-0.4 (r=0.396, p<0.05).

• 

  Fig. 2 There was a significant linear correlation between common carotid artery IMT and LhbaPWV. The equation of slope is Y=1.030E-0.4X -2.0E-0.2 (r=0.51, p<0.05).

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