J Korean Med Sci.  2014 May;29(5):714-718. 10.3346/jkms.2014.29.5.714.

Difference of the Naltrexone's Effects in Social Drinkers by Spicy Food Preference

• Lee JS
• Kim SG
• Jeong HJ
• Kim JH
• Yang YH
• Jung WY

• KMID: 1786115
• DOI: http://doi.org/10.3346/jkms.2014.29.5.714

Abstract

The purpose of this study was to investigate the differences in subjective acute effects of alcohol and naltrexone among those who prefer spicy food to varying degrees. Acute biphasic alcohol effects scale (BAES), visual analogue scale for craving (VAS-C), blood alcohol concentration (BAC) and food preference scale were measured in 26 men. Repeated measures ANOVA (2 preference groupsx4 time blocks) on the stimulative subscale of BAES revealed a significant group by block interaction in naltrexone condition (N+) (P<0.001), but not in non-naltrexone condition (N-). Furthermore, repeated measures ANOVA (2 drug groupsx4 time blocks) on the stimulative subscale of BAES revealed a significant group by block interaction in strong preference for spicy food (SP) (P<0.001), but not in lesser preference for spicy food (LP). The paired t-test revealed that significant suppression of the stimulative subscale of BAES was observed at 15 min (P<0.001) and 30 min (P<0.001) after drinking when N+ compared with N- in SP. For those who prefer spicy food, the stimulative effect of acute alcohol administration was suppressed by naltrexone. This result suggests that the effect of naltrexone may vary according to spicy food preference.

Keyword

Spicy Food Preference; Capsaicin; Naltrexone; Alcohols

MeSH Terms

Adult
Alcohol Drinking/*adverse effects
Alcoholism/*drug therapy
Capsaicin/pharmacology
Food Preferences/*drug effects
Humans
Male
Naltrexone/adverse effects/*therapeutic use
Narcotic Antagonists/adverse effects/*therapeutic use
Questionnaires
Sensory System Agents/pharmacology
Young Adult
Capsaicin
Naltrexone
Narcotic Antagonists
Sensory System Agents

Figure

• 

  Fig. 1 Total score of 12 stimulative subscale items using the BAES after drinking 0.6 mL/kg of alcohol. BAES, Biphasic Alcohol Effects Scale; LP, lesser preference for spicy food; SP, strong preference for spicy food; N+, naltrexone condition; N-, non-naltrexone condition. *P<0.001 between SP-N+ and SP-N- by paired t-test.

Reference

1. Herz A. Endogenous opioid systems and alcohol addiction. Psychopharmacology (Berl). 1997; 129:99–111.

2. Goodwin DW, Davis DH, Robins LN. Drinking amid abundant illicit drugs: the Vietnam case. Arch Gen Psychiatry. 1975; 32:230–233.

3. Patel VA, Pohorecky LA. Acute and chronic ethanol treatment on beta-endorphin and catecholamine levels. Alcohol. 1989; 6:59–63.

4. Hubbell CL, Abelson ML, Burkhardt CA, Herlands SE, Reid LD. Constant infusions of morphine and intakes of sweetened ethanol solution among rats. Alcohol. 1988; 5:409–415.

5. Volpicelli JR, Watson NT, King AC, Sherman CE, O'Brien CP. Effect of naltrexone on alcohol "high" in alcoholics. Am J Psychiatry. 1995; 152:613–615.

6. O'Malley SS, Jaffe AJ, Chang G, Schottenfeld RS, Meyer RE, Rounsaville B. Naltrexone and coping skills therapy for alcohol dependence: a controlled study. Arch Gen Psychiatry. 1992; 49:881–887.

7. Volpicelli JR, Alterman AI, Hayashida M, O'Brien CP. Naltrexone in the treatment of alcohol dependence. Arch Gen Psychiatry. 1992; 49:876–880.

8. Laaksonen E, Koski-Jännes A, Salaspuro M, Ahtinen H, Alho H. A randomized, multicentre, open-label, comparative trial of disulfiram, naltrexone and acamprosate in the treatment of alcohol dependence. Alcohol Alcohol. 2008; 43:53–61.

9. Garbutt JC. Efficacy and tolerability of naltrexone in the management of alcohol dependence. Curr Pharm Des. 2010; 16:2091–2097.

10. Laaksonen E, Lahti J, Sinclair JD, Heinälä P, Alho H. Predictors for the efficacy of naltrexone treatment in alcohol dependence: sweet preference. Alcohol Alcohol. 2011; 46:308–311.

11. Garbutt JC, Osborne M, Gallop R, Barkenbus J, Grace K, Cody M, Flannery B, Kampov-Polevoy AB. Sweet liking phenotype, alcohol craving and response to naltrexone treatment in alcohol dependence. Alcohol Alcohol. 2009; 44:293–300.

12. Kim SG. Effect of capsaicin on alcohol intake in C57BL/6 mice. J Korean Neuropsychiatr Assoc. 2004; 43:564–569.

13. Lee JS, Kim SG, Kim HK, Baek SY, Kim CM. Acute effects of capsaicin on proopioimelanocortin mRNA levels in the arcuate nucleus of Sprague-Dawley rats. Psychiatry Investig. 2012; 9:187–190.

14. Jeong HJ, Kim SG, Kim JH, Park SH, Kang CJ. The impact of hot food preferences on naltrexone's effects on subjective acute responses to alcohol in social drinkers. J Korean Neuropsychiatr Assoc. 2007; 46:566–572.

15. Bach FW, Yaksh TL. Release of beta-endorphin immunoreactivity into ventriculo-cisternal perfusate by lumbar intrathecal capsaicin in the rat. Brain Res. 1995; 701:192–200.

16. Martin CS, Earleywine M, Musty RE, Perrine MW, Swift RM. Development and validation of the Biphasic Alcohol Effects Scale. Alcohol Clin Exp Res. 1993; 17:140–146.

17. O'Malley SS, Jaffe AJ, Chang G, Rode S, Schottenfeld R, Meyer RE, Rounsaville B. Six-month follow-up of naltrexone and psychotherapy for alcohol dependence. Arch Gen Psychiatry. 1996; 53:217–224.

18. Jaffe AJ, Rounsaville B, Chang G, Schottenfeld RS, Meyer RE, O'Malley SS. Naltrexone, relapse prevention, and supportive therapy with alcoholics: an analysis of patient treatment matching. J Consult Clin Psychol. 1996; 64:1044–1053.

19. Monterosso JR, Flannery BA, Pettinati HM, Oslin DW, Rukstalis M, O'Brien CP, Volpicelli JR. Predicting treatment response to naltrexone: the influence of craving and family history. Am J Addict. 2001; 10:258–268.

20. Volpicelli JR, Clay KL, Watson NT, O'Brien CP. Naltrexone in the treatment of alcoholism: predicting response to naltrexone. J Clin Psychiatry. 1995; 56:39–44.

21. Kim JH, Kim SG, Shin SH, Park JM, Kim MJ. Effect of naltrexone on acute alcohol response in social drinker. J Korean Neuropsychiatr Assoc. 2004; 43:689–696.

22. Cabanac M. Sensory pleasure. Q Rev Biol. 1979; 54:1–29.

23. Berridge KC. Food reward: brain substrates of wanting and liking. Neurosci Biobehav Rev. 1996; 20:1–25.

24. Kampov-Polevoy AB, Eick C, Boland G, Khalitov E, Crews FT. Sweet liking, novelty seeking, and gender predict alcoholic status. Alcohol Clin Exp Res. 2004; 28:1291–1298.

25. Kampov-Polevoy AB, Garbutt JC, Khalitov E. Family history of alcoholism and response to sweets. Alcohol Clin Exp Res. 2003; 27:1743–1749.

26. Driscoll KA, Perez M, Cukrowicz KC, Butler M, Joiner TE Jr. Associations of phenylthiocarbamide tasting to alcohol problems and family history of alcoholism differ by gender. Psychiatry Res. 2006; 143:21–27.

27. Hinrichs AL, Wang JC, Bufe B, Kwon JM, Budde J, Allen R, Bertelsen S, Evans W, Dick D, Rice J, et al. Functional variant in a bitter-taste receptor (hTAS2R16) influences risk of alcohol dependence. Am J Hum Genet. 2006; 78:103–111.