Korean J Anesthesiol.  2008 Dec;55(6):691-699. 10.4097/kjae.2008.55.6.691.

Effects of magnesium infusion on hemodynamic and autonomic changes in healthy volunteers

• Kim TH
• Kang SJ
• Sang BH
• Shin WJ
• Kim YK
• Hwang GS
• Han SM

• KMID: 1782544
• DOI: http://doi.org/10.4097/kjae.2008.55.6.691

Abstract

BACKGROUND: Magnesium has been used for treatments and preventions of various situations, such as cardiovascular disease and pre-eclampsia. And it also used for decreasing demands of anesthetics and analgesics during anesthesia. Activity of autonomic nervous system has important roles for homeostasis of cardiovascular system, and its dysfunction affects mortality and morbidity. Because there are few reports about effects of magnesium infusion on autonomic nervous system, we investigated effects of magnesium infusion on hemodynamic and autonomic changes using variable autonomic function tests in healthy volunteers.
METHODS
Hemodynamic parameters, heart rate variability, blood pressure variability, and baroreflex sensitivity were evaluated before and after magnesium infusion of 30 mg/kg during 20 min in twenty healthy volunteers. Cold face test, valsalva maneuver were also performed before and after magnesium infusion.
RESULTS
Low-frequency components of blood pressure variability decreased after magnesium infusion (P = 0.026). There were no significant differences in blood pressure, heart rate, cardiac output, stroke volume, total peripheral resistance, heart rate variablility and baroreflex sensitivity between before and after magnesium infusion. Increases of diastolic blood pressure during cold face test decreased significantly after magnesium infusion (P = 0.022). In addition, no significant hemodynamic and autonomic changes were found during valsalva maneuver.
CONCLUSIONS
Central sympathetic vasomotor tone decreased after magnesium infusion of 30 mg/kg during 20 min in healthy volunteers. However, it had no effects on parasympathetic system and baroreflex sensitivity.

Keyword

autonomic nervous system; cardiovascular variability; cold face test; magnesium; valsalva maneuver

MeSH Terms

Analgesics
Anesthesia
Anesthetics
Autonomic Nervous System
Baroreflex
Blood Pressure
Cardiac Output
Cardiovascular Diseases
Cardiovascular System
Cold Temperature
Heart Rate
Hemodynamics
Homeostasis
Magnesium
Pre-Eclampsia
Stroke Volume
Valsalva Maneuver
Vascular Resistance
Analgesics
Anesthetics
Magnesium