J Korean Med Sci.  2005 Feb;20(1):20-25. 10.3346/jkms.2005.20.1.20.

New Parameters for Left Ventricular Function in Atrial Fibrillation: Based on the Relationship between RR Interval and Performance

• Ko HS
• Kim CJ
• Ryu WS

• KMID: 1781718
• DOI: http://doi.org/10.3346/jkms.2005.20.1.20

Abstract

This study was designed to obtain new parameters representing left ventricular (LV) function independent of irregular RR intervals in atrial fibrillation (AF). AF patients were divided into Normal (n=9) and LV Dysfunction (n=9) groups. The relations between LV outflow peak ejection velocity (Vpe) and preceding (RR-1) or prepreceding RR intervals (RR-2) were obtained using logarithmic equations, from which the squared correlation coefficient (r2), slope, Vpe at RR-1 or RR-2=1 sec (Vpe-1), and the ratio of slope to Vpe-1 (Slope/Vpe-1) were calculated. Among the parameters between RR-1 and Vpe, Slope/Vpe-1 was higher in LV Dysfunction group than in Normal group (p=0.05). When only coordinates with RR-1 from 0.6 to 1 sec were included, Slope/Vpe-1 (p=0.001) was higher in LV Dysfunction group than in Normal group. Among the parameters between RR-2 and Vpe, Slope/Vpe-1, slope, and r2 were different between the two groups. In multivariate analysis, Slope/Vpe-1 between RR-2 and Vpe was only independent parameter. However, Slope/Vpe-1 between RR-1 and Vpe in the coordinates with RR-1 from 0.6 to 1 sec had the highest discriminating power. New parameters derived from the relations between RR intervals and LV performance might be useful to evaluate LV function quantitatively in AF.

Keyword

Atrial Fibrillation; Electrocardiography; Echocardiography, Doppler, Pulsed; Stroke Volume

MeSH Terms

Age Factors
Aged
Atrial Fibrillation/*metabolism
Atrial Function, Left
Echocardiography
Echocardiography, Doppler, Pulsed
Electrocardiography
Female
Heart/physiology
Heart Ventricles
Hemodynamic Processes
Humans
Male
Middle Aged
Models, Theoretical
Multivariate Analysis
Myocardial Contraction
Myocardium/pathology
Time Factors
*Ventricular Function, Left

Figure

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  Fig. 1 Differences of new parameters representing LV function between Normal and LV Dysfunction groups in atrial fibrillation. (A) Slope/Vpe-1 in the relation between RR-2 and Vpe, (B) Slope/Vpe-1 in the relation between RR-1 and Vpe and (C) Slope/Vpe-1 in the relation between RR-1 and Vpe in the coordinates with RR-1 from 0.6 to 1 sec.

• 

  Fig. 2 The relations between (A) pre-preceding RR interval (RR-2) or (B) preceding RR interval (RR-1) and LV performance (Vpe) in Normal and LV Dysfunction groups.

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  Fig. 3 The relations between fractional shortening and new parameters representing LV function in atrial fibrillation. (A) Slope/Vpe-1 in the relation between RR-2 and Vpe, and (B) Slope/Vpe-1 in the relation between RR-1 and Vpe in coordinates with RR-1 from 0.6 to 1 sec.

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