Ann Lab Med.  2013 Sep;33(5):383-385. 10.3343/alm.2013.33.5.383.

The First Case of Septicemia Caused by Imipenem-Susceptible, Meropenem-Resistant Klebsiella pneumoniae

• Kayama S
• Shigemoto
• Kuwahara R
• Ishino T
• Imon K
• Onodera M
• Yokozaki M
• Ohge H
• Sugai M

• KMID: 1781349
• DOI: http://doi.org/10.3343/alm.2013.33.5.383

Abstract

No abstract available.

MeSH Terms

Aged
Drug Resistance, Bacterial
Humans
Imipenem/pharmacology/therapeutic use
Klebsiella Infections/diagnosis/drug therapy/*microbiology
Klebsiella pneumoniae/drug effects/isolation & purification/*physiology
Male
Microbial Sensitivity Tests
Phenotype
Sepsis/diagnosis/drug therapy/*microbiology
Thienamycins/pharmacology/therapeutic use
Imipenem
Thienamycins

Figure

• 

  Fig. 1 Phenotypic detection of extended spectrum β-lactamase and carbapenemases in the K1 isolate, an imipenem-susceptible meropenem-resistant Klebsiella pneumoniae strain isolated from venous blood. (A) DDST with amoxicillin/clavulanate. K. pneumoniae K1 was inoculated onto the surface of a Muller-Hinton agar plate. Cephalosporin disks were applied at a distance of 20 mm from the clavulanate-containing disk; an enhanced zone of inhibition toward the clavulanate-containing disk was observed. (B) SMA test using IPM and MEM. K. pneumoniae K1 was inoculated onto the surface of a Muller-Hinton agar plate. An SMA disk was placed adjacent to either the IPM or MEM disk; an enhanced zone of inhibition toward the SMA disk was observed. (C) Modified Hodge test using IPM or MEM. E. coli ATCC25922 was inoculated onto the surface of a Muller-Hinton agar plate and organisms (K1, K5, K. pneumoniae ATCC BAA-1705 for positive control and K. pneumoniae ATCC BAA-1706 for negative control) were inoculated as streaks.Abbreviations: A/C, amoxicillin/clavulanate; CTX, cefotaxime; CPR, cefpirome; CAZ, ceftazidime; CFPM, cefepime; DDST, double-disk synergy test; IPM, imipenem; MEM, meropenem; SMA, sodium mercaptoacetic acid.

Reference

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