Yonsei Med J.  2010 Nov;51(6):901-911. 10.3349/ymj.2010.51.6.901.

Increase of Ceftazidime- and Fluoroquinolone-Resistant Klebsiella pneumoniae and Imipenem-Resistant Acinetobacter spp. in Korea: Analysis of KONSAR Study Data from 2005 and 2007

Affiliations
  • 1Department of Laboratory Medicine, Yonsei University College of Medicine, Seoul, Korea. whonetkor@yuhs.ac
  • 2Department of Laboratory Medicine, Ewha Womans University Mokdong Hospital, Seoul, Korea.
  • 3Department of Laboratory Medicine, Yeungnam University Hospital, Daegu, Korea.
  • 4Department of Laboratory Medicine, Konyang University Hospital, Daejeon, Korea.
  • 5Department of Laboratory Medicine, Gyeongsang National University Hospital, Jinju, Korea.
  • 6Department of Laboratory Medicine, Inha University Hospital, Incheon, Korea.

Abstract

PURPOSE
Antimicrobial resistance monitoring could be a useful source of information for treating and controlling nosocomial infections. We analyzed antimicrobial resistance data generated by Korean Hospitals and by a commercial laboratory in 2005 and 2007.
MATERIALS AND METHODS
Susceptibility data for 2005 and 2007 were collected from 37 and 41 hospitals, respectively, and from one commercial laboratory. Intermediate susceptibility was not included in the calculation of resistance rates.
RESULTS
Methicillin-resistant Staphylococcus aureus (MRSA) (64%), third-generation cephalosporin-resistant Klebsiella pneumoniae (29%), fluoroquinolone-resistant Escherichia coli (27%), Pseudomonas aeruginosa (33%), and Acinetobacter spp. (48%), and amikacin-resistant P. aeruginosa (19%) and Acinetobacter spp. (37%) were prevalent in hospitals in 2007. A gradual increase of vancomycin-resistant Enterococcus faecium and imipenem-resistant Acinetobacter spp. was observed. Higher incidences of third-generation cephalosporin-resistant E. coli and K. pneumoniae and imipenem-resistant P. aeruginosa were found in the commercial laboratory than in the hospitals.
CONCLUSION
Methicillin-resistant S. aureus, third-generation cephalosporin-resistant K. pneumoniae, and fluoroquinolone-resistant E. coli, P. aeruginosa and Acinetobacter spp. remain prevalent in Korea, while the incidence of vancomycin-resistant E. faecium and imipenem-resistant Acinetobacter spp. has increased gradually. The higher prevalences of third-generation cephalosporin-resistant E. coli and K. pneumoniae, and imipenem-resistant P. aeruginosa in the commercial laboratory are a new concern.

Keyword

Antimicrobial resistance surveillance; Korea; vancomycin resistance; fluoroquinolone resistance; imipenem resistance; MRSA; P. aeruginosa; Acinetobacter spp.

MeSH Terms

Acinetobacter/*metabolism
Bacterial Infections/drug therapy/*epidemiology
Ceftazidime/*pharmacology
Cross Infection/drug therapy/*epidemiology
*Drug Resistance, Bacterial
Escherichia coli/metabolism
Fluoroquinolones/*pharmacology
Humans
Imipenem/*pharmacology
Klebsiella Infections/*drug therapy
Klebsiella pneumoniae/*metabolism
Methicillin-Resistant Staphylococcus aureus/metabolism
Pseudomonas aeruginosa/metabolism
Republic of Korea
Vancomycin/pharmacology
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