J Korean Med Sci.  2013 May;28(5):693-699. 10.3346/jkms.2013.28.5.693.

Differentiated Thyroid Carcinoma of Children and Adolescents: 27-Year Experience in the Yonsei University Health System

  • 1Department of Surgery, Yonsei University College of Medicine, Seoul, Korea. jungjongj@yuhs.ac


Thyroid carcinomas are uncommon in childhood and adolescence. The aim of this study was to analyze clinical features and clinical outcomes of thyroid cancer in the pediatric population treated in the Yonsei University Health System. From September 1982 to June 2009, 90 patients (75 females, 15 males; female:male ratio of 5:1) with differentiated thyroid carcinoma were identified in our institute. The mean age at diagnosis was 15.8 yr old (range 4.8-19.9 yr). Cervical masses were most common clinical manifestations at diagnosis in 65 patients (72.2%). Forty-two patients underwent less than total thyroidectomy and 18 patients underwent total thyroidectomy. Thirty patients (33.3%) had lateral neck lymph node metastasis and seven patients (7.8%) had lung metastasis at the time of surgery. Among the 90 patients, recurrence occurred in 14 patients (15.5%). Mean follow-up period for patients with differentiated thyroid carcinoma was 81.6 months (13-324 months). No patients died of differentiated thyroid carcinoma. Patients with differentiated thyroid carcinoma who were < 20-yr-of-age were present with aggressive local disease and a high frequency of lymph node and distant metastasis. It is recommended that pediatric thyroid cancer should be managed mostly using proper surgical approach with thyroidectomy and lymph node dissection when indicated.


Pediatric Thyroid Cancer; Differentiated Thyroid Cancer; Clinical Outcome; Children and Adolescents; Survival Rate

MeSH Terms

Age Factors
Child, Preschool
Follow-Up Studies
Hospitals, University
Iodine Radioisotopes/therapeutic use
Lung Neoplasms/diagnosis/secondary
Lymph Node Excision
Lymph Nodes/surgery
Lymphatic Metastasis
Survival Rate
Thyroid Neoplasms/*pathology/radiotherapy/surgery
Young Adult
Iodine Radioisotopes


  • Fig. 1 Recurrence free survival rate in pediatric patients with differentiated thyroid carcinoma.

  • Fig. 2 Comparison with recurrence free survival rate among the different age groups.

Cited by  1 articles

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Kwangsoon Kim, Won Woong Kim, Jung Bum Choi, Min Jhi Kim, Cho Rok Lee, Jandee Lee, Sang-Wook Kang, Kee-Hyun Nam, Woong Youn Chung, Jong Ju Jeong
Ann Surg Treat Res. 2018;95(4):222-229.    doi: 10.4174/astr.2018.95.4.222.


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