Korean J Gastroenterol.  2009 Aug;54(2):99-107. 10.4166/kjg.2009.54.2.99.

Predictive Significance of Serum IL-6, VEGF, and CRP in Gastric Adenoma and Mucosal Carcinoma before Endoscopic Submucosal Dissection

• Jang JS
• Choi SR
• Han SY
• Roh MH
• Lee JH
• Lee SW
• Jeung JS
• Kim MC
• Son YK
• Baek YH

• KMID: 1775964
• DOI: http://doi.org/10.4166/kjg.2009.54.2.99

Abstract

BACKGROUND/AIMS
Endoscopic submucosal dissection (ESD) is commonly used for radical resection of gastric adenoma and mucosal cancer, but there is about 30% of discrepancy rate between the histology of the endoscopic biopsy and that of the resecwas to clarify the clinical significance of IL-6, VEGF, CRP before ESD. METHODS: We investigated the correlation between serum IL-6, VEGF, CRP level and discrepancy rate of gastric neoplastic lesions (10 low-grade dysplasias, 18 high-grade dysplasias, and 25 early gastic cancers). RESULTS: Serum levels of IL-6 in gastric adenoma and mucosal cancer patients were significantly higher than in healthy controls (p<0.05). Especially, serum IL-6 level of high-grade dysplasia patient was significantly higher than low-grade dysplasia and mucosal cancer patients, and the positive rate, sensitivity, and negative predictive value of serum IL-6 levels were higher in high-grade dysplasia patient compared to low-grade dysplasia patient and mucosal cancer patient. Serum levels of VEGF in patients with gastric adenoma and mucosal cancer were significantly higher than healthy controls (p<0.01). Serum levels of CRP in patients with mucosal cancer were significantly higher than in the controls (p<0.05), and the positive rate, sensitivity, and positive predictive value of serum CRP levels were higher in high-grade dysplasia and mucosal cancer patients compared to low-grade dysplasia patient. CONCLUSIONS: Serum levels of IL-6, VEGF, and CRP in patients with gastric neoplastic lesions were significantly higher than healthy controls, especially, serum IL-6 level of high grade dysplasia patient was significantly higher than low-grade dysplasia and mucosal cancer patients.

Keyword

Serum IL-6; VEGF; CRP; Adenoma; Cancer

MeSH Terms

Adenoma/*diagnosis/pathology/surgery
Adult
Aged
C-Reactive Protein/*analysis
Carcinoma/*diagnosis/pathology/surgery
Diagnosis, Differential
Female
Gastric Mucosa/*surgery
Gastroscopy
Humans
Interleukin-6/*blood
Male
Middle Aged
Predictive Value of Tests
Stomach Neoplasms/*diagnosis/pathology/surgery
Vascular Endothelial Growth Factors/*blood

Figure

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  Fig. 1. Pathologic findings after endoscopic sbumucosal dissection: low-grade dysplasia (A), high-grade dysplasia (B), and mucosal cancer (C) (H&E stain, ×400).

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  Fig. 2. Serum levels of IL-6 in controls, gastric adenoma and mucosal cancer patients. LGD, low-grade dysplasia; HGD, high-grade dysplasia; EGC, early gastric cancer.

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  Fig. 3. Serum levels of VEGF in controls, gastric adenoma and mucosal cancer patients. LGD, low-grade dysplasia; HGD, high-grade dysplasia; EGC, early gastric cancer.

• 

  Fig. 4. Serum levels of CRP in controls, gastric adenoma, and mucosal cancer patients. LGD, low-grade dysplasia; HGD, high-grade dysplasia; EGC, early gastric cancer.

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