Gut Liver.  2014 Mar;8(2):186-195.

The Expression of Programmed Death-1 in Circulating CD4+ and CD8+ T Cells during Hepatitis B Virus Infection Progression and Its Correlation with Clinical Baseline Characteristics

  • 1The Affiliated Infectious Hospital of Soochow University, Suzhou, China.
  • 2Key Laboratory of Infection and Immunity of Suzhou City, Suzhou, China.
  • 3Medical Biotechnology Institute, Medical College of Soochow University, Suzhou, China.
  • 4School of Biology and Basic Medical Sciences, Medical College of Soochow University, Suzhou, China.


Programmed death-1 (PD-1) expression was investigated in CD4+ and CD8+ T cells from hepatitis B virus (HBV)-infected patients at the chronic hepatitis B (CHB) infection, liver cirrhosis (LC), and hepatocellular carcinoma (HCC) stages.
PD-1 expression in circulating CD4+ and CD8+ T cells was detected by flow cytometry. The correlations between PD-1 expression and HBV viral load, alanine aminotransaminase (ALT) levels and aspartate aminotransferase (AST) levels were analyzed using GraphPad Prism 5.0.
PD-1 expression in CD4+ and CD8+ T cells was significantly increased in both the CHB group and advanced-stage group (LC plus HCC). In the CHB group, PD-1 expression in both CD4+ and CD8+ T cells was positively correlated with the HBV viral load, ALT, and AST levels. However, in the LC plus HCC group, significant correlations between PD-1 expression and the clinical parameters were nearly absent.
PD-1 expression in peripheral CD4+ and CD8+ T cells is dynamic, changes with HBV infection progression, and is related to HBV viral load and liver function, especially in CHB. PD-1 expression could be utilized as a potential clinical indicator to determine the extent of virus replication and liver injury.


Programmed death-1; Hepatitis B virus; Hepatitis B, chronic; Liver cirrhosis; Carcinoma, hepatocellular

MeSH Terms

CD4-Positive T-Lymphocytes/*metabolism
CD8-Positive T-Lymphocytes/*metabolism
Carcinoma, Hepatocellular
Disease Progression
Hepatitis B, Chronic/*diagnosis/immunology
Liver Cirrhosis
Liver Neoplasms
Programmed Cell Death 1 Receptor/*metabolism
Viral Load
Programmed Cell Death 1 Receptor
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