Korean J Anesthesiol.  1989 Jun;22(3):374-384. 10.4097/kjae.1989.22.3.374.

A Comparative Study of Effects of Netroglycerin , Adenosine Triphosphate and Sodium Nitroprusside on the Hemodynamic and Blood Gas Analysis Changes during Epinephrine Infusion in Air Embolized Cats

• Woo SH
• Han SM
• Suh BT

• KMID: 1751751
• DOI: http://doi.org/10.4097/kjae.1989.22.3.374

Abstract

Effects of nitroglycerin (NTC), adenosine triphosphate (ATP) and sodium nitroprusside (SNP) on the hemodynamic and blood gas analysis changes epinephrine (EPI) infusion is air embolized cats were investigated. Under the general anesthesia with pentobarbital and vecuronium cats were given 2~2.5 ml/kg of air via internal jugular vein and were resuscitated with EPI bolus injection. Thirty two cats were divided into 4 groups of 8 each. Each 4 groups, were administered saline (group1), NTG (group 2), ATP (group 3) and SNP (group 4) with EPI continuous infusion, respectively. The air shadow in the heart of cats was visualized C-arm image intensifier throught the study and all three vasodilators augmented the removal of air from the heart on C-arm image. All three vasodilators therapy groups produced statistically significant decrease in rate pressure product (p<0.05) but only NTG therapy group decreased heart rate (p<0.05). Central venous pressure were decreased in all three vasodilators therapy groups but only NTG therapy group was statistically significant (p<0.05). Only NTG therapy group increased both arterial (p<0.05) and venous oxgenation. These results indicate that NTG therapy group produced more prominant hemodynamic and blood oxygenation improvement than the other three groups. It is concluded that NTG with vasopressor therapy coude be recommended in venous air embolism.

Keyword

Complication: venous air embolism; Hemodynamics: rate pressure products; Blood gas analysis: artery; vein; Pharmacology: Epinephrine; Nitroglycerin; Adenosine triphophate; Sodium nitroprusside

MeSH Terms

Adenosine Triphosphate*
Adenosine*
Anesthesia, General
Animals
Blood Gas Analysis*
Cats*
Central Venous Pressure
Embolism, Air
Epinephrine*
Heart
Heart Rate
Hemodynamics*
Jugular Veins
Nitroglycerin
Nitroprusside*
Oxygen
Pentobarbital
Sodium*
Vasodilator Agents
Vecuronium Bromide
Adenosine
Adenosine Triphosphate
Epinephrine
Nitroglycerin
Nitroprusside
Oxygen
Pentobarbital
Sodium
Vasodilator Agents
Vecuronium Bromide