Asian Spine J.
2012 Jun;6(2):115-122. 10.4184/asj.2012.6.2.115.
Clinical Comparative Study: Efficacy and Tolerability of Tolperisone and Thiocolchicoside in Acute Low Back Pain and Spinal Muscle Spasticity
- Affiliations
-
- 1Department of Orthopedics, Jubilee Missions Medical College, Thrissur, India.
- 2Department of Orthopedics, Sanjeevani Hospital, Mumbai, India.
- 3Department of Orthopedics, Sir JJ Group of Hospitals, Mumbai, India.
- 4Department of Orthopedics, Nightingale Hospital, Kolkata, India.
- 5Department of Orthopedics, Kothari Medical Center, Kolkata, India.
- 6Department of Orthopaedics, Kolkata Medical College, Kolkata, India.
- 7Department of Orthopaedics, All India Institute of Medical Sciences (AIIMS), Delhi, India. prakash.kotwal@gmail.com
- KMID: 1743282
- DOI: http://doi.org/10.4184/asj.2012.6.2.115
Abstract
- STUDY DESIGN: We performed a multicentric, randomized, comparative clinical trial. Eligible patients were randomly assigned to receive 150 mg of Tolperisone thrice daily or 8 mg of Thiocolchicoside twice daily for 7 days.
PURPOSE: To assess the efficacy and tolerability of Tolperisone in comparison with Thiocolchicoside in the treatment of acute low back pain with spasm of spinal muscles.
OVERVIEW OF LITERATURE: No head on clinical trial of Tolperisone with Thiocolchicoside is available and so this study is done.
METHODS
The assessment of muscle spasm was made by measuring the finger-to-floor distance (FFD), articular excursion in degrees on performing Lasegue's maneuver and modified Schober's test. Assessment of pain on movement and spontaneous pain (pain at rest) of the lumbar spine was made with the help of visual analogue scale score.
RESULTS
The improvement in articular excursion on Lasegue's maneuver was significantly greater on day 3 (p = 0.017) and day 7 (p = 0.0001) with Tolperisone as compared to Thiocolchicoside. The reduction in FFD score was greater on day 7 (p = 0.0001) with Tolperisone. However there was no significant difference in improvement in Schober's test score on day 3 (p = 0.664) and day 7 (p = 0.192). The improvement in pain score at rest and on movement was significantly greater with Tolperisone (p = 0.0001).
CONCLUSIONS
Tolperisone is an effective and well tolerated option for treatment of patients with skeletal muscle spasm associated with pain.
- Full Text Links
-
- Actions
-
Cited
- CITED
-
- Close
- Share
-
- Similar articles
-
- Treatment of Tremor and Spasticity in Failed Back Surgery Syndrome with Spinal Cord Stimulation: A case report
- Lumbar Epidural Steroid Injection for Painful Spasticity in Cervical Spinal Cord Injury: A Case Report
- The Effect of Spinal Manipulation for Patients with Acute Low Back Pain
- A Clinical Study of Low Back Pain
- Atrophy of Multifidus Muscle on Low Back Pain Patients
