J Korean Burn Soc.  2011 Jun;14(1):12-15.

Effect of Ascorbic Acid at Early Fluid Resuscitation in Severe Burn Injured Patients

• Son YH
• Jang YH
• Kim SK
• Park JM
• Lee MY

Abstract

PURPOSE
Ascorbic acid is a potent antioxidant capable of scavenging oxygen free radicals. We investigated the effect of ascorbic acid on initial management of a major burn.
METHODS
A total of twenty two patients with extent of burn injury greater than 30% of the body surface area (BSA) were enrolled. Early fluid resuscitation was performed with Parkland formula (<40% BSA) and modified hypertonic formula (> or =40% BSA). In ascorbic acid group, ascorbic acid was continuously infused at a dose of 30 mg/kg/h during first 24 hours of fluid resuscitation. Target urine output was 0.5~1 ml/kg/h.
RESULTS
There were no significant differences in age, sex, and BSA among the groups. In the cases of Parkland formula, there was no significant difference in the fluid requirement between control group (4.26+/-1.29 ml/kg/%burn) and ascorbic acid group (3.53+/-0.87 ml/kg/%burn). However, in the cases of modified hypertonic formula, there was significant difference in the fluid requirement between control group (3.31+/-0.95 ml/kg/%burn) and ascorbic acid group (2.34+/-0.35 ml/kg/%burn).
CONCLUSION
High-dose ascorbic acid reduces fluid requirement at early fluid resuscitation in severely burned patients managed with modified hypertonic formula.

Keyword

Ascorbic acid; Burn; Fluid therapy

MeSH Terms

Ascorbic Acid
Body Surface Area
Burns
Fluid Therapy
Free Radicals
Humans
Oxygen
Resuscitation
Ascorbic Acid
Free Radicals
Oxygen