Yonsei Med J.  2004 Jun;45(3):413-418. 10.3349/ymj.2004.45.3.413.

Iron Supplementation in Experimental Hyperthyroidism: Effects on Oxidative Stress in Skeletal Muscle Tissue

• Seymen HO
• Civelek S
• Seven A
• Yigit G
• Hatemi H
• Burcak G

• KMID: 1734122
• DOI: http://doi.org/10.3349/ymj.2004.45.3.413

Abstract

This study was designed to investigate the effects of iron supplementation on the parameters of oxidative stress in the skeletal muscle tissue of hyperthyroidism induced rats. Hyperthyroidism was found to cause an increase in thiobarbituric acid-reactive substances (TBARS) and copper zinc superoxide dismutase (Cu, Zn SOD) activity, but decreases in the glutathione-peroxidase (GSH Px) activity and glutathione (GSH). Iron supplementation caused an increase in TBARS and a decrease in GSH. Iron supplementation in hyperthyroid rats attenuated the hyperthyroid state, but lowered the plasma ferritin level, which is considered an indicator of thyroid hormone action. Iron supplementation caused no additional increase in the TBARS in hyperthyroid rats, ameliorated the decrease in GSH content and abolished the induction of Cu, Zn SOD. Our findings suggested no increase, but a decrease, in the risk of oxidative stress in iron supplemented hyperthyroid rats. Whether supplementation of iron would have similar effects in humans should be further investigated in clinical studies.

Keyword

Hyperthyroidism; iron supplementation; skeletal muscle; lipid peroxidation; antioxidant status; ferritin

MeSH Terms

Animals
Glutathione/metabolism
Human
Hyperthyroidism/*metabolism
Iron/*pharmacology
Lipid Peroxidation/drug effects
Male
Muscle, Skeletal/*metabolism
Oxidative Stress/*drug effects
Rats
Rats, Wistar
Superoxide Dismutase/metabolism
Thiobarbituric Acid Reactive Substances/metabolism
Triiodothyronine/blood