J Vet Sci.  2025 Jan;26(1):e3. 10.4142/jvs.24246.

First report of iron-overload myopathy due to secondary hemochromatosis in a dog

• Yim JH
• Kim TU
• Kim WJ
• Bae S
• Yun S
• Baek SM
• Park JK

• KMID: 2565096
• DOI: http://doi.org/10.4142/jvs.24246

Abstract

Importance
Hemochromatosis is rare in domestic animals, and iron-induced myopathy has not been reported in veterinary medicine. This case is the first report of iron-overload myopathy owing to hemochromatosis in a dog.
Case presentation
A 9-year-old spayed female Donggyeong dog presented with severe forelimb lameness. Necropsy revealed an enlarged liver and hemorrhagic lesions in the forelimb muscle. Microscopy showed iron components accumulation in multiple organs, including the liver, forelimb skeletal muscle, spleen, lymph node, and kidney. Prussian blue staining identified iron deposits in both macrophages and parenchymal cells, indicating that the iron accumulation was acquired rather than hereditary. Furthermore, iron components were observed within muscle fibers, accompanied by severe atrophy and myositis.
Conclusions and Relevance
Severe necrosis and mild fibrosis were observed in the liver and forelimb skeletal muscles. Based on histological analysis, we diagnosed iron overload myopathy by secondary hemochromatosis. Secondary hemochromatosis with severe muscle atrophy and myositis is very rare, and this is the first report of iron-overload myopathy in a dog.

Keyword

Iron-overload; muscular diseases; hemochromatosis; non-transferrin bound iron; lameness; animal