J Korean Med Sci.  2004 Apr;19(2):294-296. 10.3346/jkms.2004.19.2.294.

Autoimmune Hemolytic Anemia in a Patient with Primary Ovarian Non-Hodgkin's Lymphoma

• Jung CK
• Park JS
• Lee EJ
• Kim SH
• Kwon HC
• Kim JS
• Roh MS
• Yoon SK
• Kim KH
• Han JY
• Kim HJ

• KMID: 1733493
• DOI: http://doi.org/10.3346/jkms.2004.19.2.294

Abstract

The primary ovarian lymphoma is a rare disease with poor prognosis. The incidence of autoimmune hemolytic anemia in patients with non-Hodgkin's lymphoma is estimated at 3%. However, a substantial portion of the previously reported cases of ovarian lymphoma actually represented ovarian involvement by more diffuse lymphomatous process. If stringent criteria are used for case selection, true primary ovarian lymphoma usually carries a favorable prognosis. We present a primary malignant lymphoma of ovary accompanied by autoimmune hemolytic anemia in a 29-yr-old patient. After ablative surgery, the hemoglobin level and the reticulocyte count were normalized. One year following surgery and chemotherapy, the patient is alive and disease free.

Keyword

Ovarian Neoplasms; Lymphoma, Non-Hodgkin; Hemolytic Anemia, Autoimmune

MeSH Terms

Adult
Anemia, Hemolytic/*immunology
Antineoplastic Agents, Hormonal/therapeutic use
Autoimmune Diseases/immunology
Combined Modality Therapy
Female
Human
Lymphoma, Non-Hodgkin/*complications/drug therapy/pathology/surgery
Ovarian Neoplasms/*complications/drug therapy/pathology/surgery
Prednisolone/therapeutic use

Figure

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  Fig. 1 Pelvis MRI showing a large mass in the pelvic cavity.

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  Fig. 2 The cut surface of the right ovarian lesion shows a solid, gray white to yellow, multilobulated tumor.

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  Fig. 3 Medium-power view of the lesion shows an organoid with small rounded nests of tumor cells surrounded by thin fibrous septae (hematoxylin and eosin, ×100).

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