Korean J Gastroenterol.  2014 Mar;63(3):141-145. 10.4166/kjg.2014.63.3.141.

Changes in the Eradication Rate of Conventional Triple Therapy for Helicobacter pylori Infection in Korea

• Heo J
• Jeon SW

• KMID: 1730924
• DOI: http://doi.org/10.4166/kjg.2014.63.3.141

Abstract

Although, the prevalence of Helicobacter pylori infection in Korea has declined owing to the eradication therapy, recent seroprevalence of H. pylori infection is still reported to be as high as 54.4%. Until now, "standard regimen" for eradication of H. pylori has been conventional triple therapy consisting of proton pump inhibitor, amoxicillin, and clarithromycin. However, with the increase in antibiotic resistance, especially against clarithromycin, the eradication rate of conventional triple therapy has steadily declined during the past 13 years in Korea. Present eradication rate of standard triple therapy is reported to be less than 80%, which is the Maginot line of efficacy for the currently available regimen. Therefore, new first line eradication regimen is needed to enhance the eradication rate of H. pylori infection.

Keyword

Helicobacter pylori; Eradication; Anti-bacterial agents

MeSH Terms

Amoxicillin/pharmacology/therapeutic use
Anti-Bacterial Agents/pharmacology/*therapeutic use
Asian Continental Ancestry Group
Clarithromycin/pharmacology/therapeutic use
Disease Eradication/trends
Drug Administration Schedule
Drug Therapy, Combination
Helicobacter Infections/*drug therapy
*Helicobacter pylori/drug effects
Humans
Proton Pump Inhibitors/therapeutic use
Republic of Korea
Amoxicillin
Anti-Bacterial Agents
Clarithromycin
Proton Pump Inhibitors

Figure

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  Fig. 1. The decreasing trend of Helicobacter pylori eradication rate with conventional triple therapy in Korea.

Reference

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