Korean J Helicobacter Up Gastrointest Res.  2015 Jun;15(2):112-116. 10.7704/kjhugr.2015.15.2.112.

Ten Years Retrospective Study about Helicobacter pylori Eradication Rate

• Jeong GW
• Sung IK

• KMID: 2249859
• DOI: http://doi.org/10.7704/kjhugr.2015.15.2.112

Abstract

BACKGROUND/AIMS
Eradication of Helicobacter pylori is a main treatment of peptic ulcer disease. A triple therapy comprised of a proton pump inhibitor, clarithromycin, and amoxicillin is the most commonly used treatment for H. pylori eradication. The eradication of H. pylori infection requires combination of antibiotics. However, development of antibiotic resistance is a major cause of treatment failure.
MATERIALS AND METHODS
This study was to observe H. pyrori eradication rate change for 10 years. From August 2005 to June 2014, a total of 4,891 patients with H. pylori infection were treated with standard H. pylori triple eradication therapy (proton pump inhibitor, amoxicillin, clarithromycin) and were analyzed by urea breath test.
RESULTS
The overall rates of eradication with standard triple therapy was 82.8% (4,048/4,891). H. pylori eradication rates decreased from 92.2% in 2005 to 80.2% in 2014 (P=0.037).
CONCLUSIONS
This study shows that the overall rate of H. pylori eradication with standard triple therapy decreased meaningfully for 10 years.

Keyword

Helicobacter pylori; Standard triple therapy; Eradication rate

MeSH Terms

Amoxicillin
Anti-Bacterial Agents
Breath Tests
Clarithromycin
Drug Resistance, Microbial
Helicobacter pylori*
Humans
Peptic Ulcer
Proton Pumps
Retrospective Studies*
Treatment Failure
Urea
Amoxicillin
Anti-Bacterial Agents
Clarithromycin
Proton Pumps
Urea