Korean J Helicobacter Up Gastrointest Res.  2015 Dec;15(4):236-242. 10.7704/kjhugr.2015.15.4.236.

Trend in the Eradication Rates of Helicobacter pylori Infection in the Last 8 Years in Daegu: A Single Center Experience

• Kim SH
• Jung JT
• Kwon JG
• Kim EY
• Kang SM
• Song JE

• KMID: 2149704
• DOI: http://doi.org/10.7704/kjhugr.2015.15.4.236

Abstract

BACKGROUND/AIMS
Helicobacter pylori eradication rates achieved by first-line triple treatment with proton pump inhibitor (PPI), clarithromycin, and amoxicillin have decreased to 70~85%, in part due to increasing antimicrobial resistance. This study evaluated the trend in H. pylori eradication rates during the most recent 8 years in Daegu, Korea and analyzed different clinical factors between success group and failure group of H. pylori eradication.
MATERIALS AND METHODS
This was a retrospective study at a single institution. A total of 768 H. pylori-positive patients who received one or two weeks of first-line triple regimens were included between January 2007 and October 2014.
RESULTS
The overall H. pylori eradication rate was 86%. The eradication rate from years 2007 to 2014 was 80.5%, 89.4%, 95.6%, 85.5%, 87.9%, 75.8%, 83.3%, and 85.8%, respectively (P=0.027). There was no significant difference in the eradication rate among various PPIs (P=0.358). In addition, there were no significant difference of clinical factors between success and failure group of H. pylori eradication.
CONCLUSIONS
The eradication rates of first-line triple therapy for H. pylori over 8 years were 75.8~95.6%. No significant difference in clinical factors were noted between success and failure group of H. pylori eradication. Triple therapy may be a useful regimen for H. pylori eradication in Daegu.

Keyword

Helicobacter pylori; Disease eradication

MeSH Terms

Amoxicillin
Clarithromycin
Daegu*
Disease Eradication
Helicobacter pylori*
Helicobacter*
Humans
Korea
Proton Pumps
Retrospective Studies
Amoxicillin
Clarithromycin
Proton Pumps