J Korean Med Sci.  2000 Aug;15(4):436-441. 10.3346/jkms.2000.15.4.436.

Concurrent chemotherapy and radiotherapy in invasive cervical cancer patients with high risk factors

• Park TK
• Kim SN
• Kim SW
• Kim GE
• Suh CO

• KMID: 1730641
• DOI: http://doi.org/10.3346/jkms.2000.15.4.436

Abstract

The aim of this study was to evaluate the survival of 395 previously untreated cervical cancer patients with at least one high risk factor following concurrent chemoradiation and to assess the toxicities. Two different chemotherapy regimens were used for concurrent chemoradiation. In the patients with squamous cell carcinoma, 100 mg/m2 of cisplatin was infused intravenously, followed immediately by five consecutive daily administrations of 5-fluorouracil, 1,000 mg/m2/day, each infused intravenously over 24 hr. As for the patients with adenocarcinoma, 70 mg/m2 of cisplatin, 250 mg/m2 of cytoxan and 45 mg/m2 of adriamycin were administered intravenously on days 1, 2, and 3, respectively. The 5-year survival rate was 54.4+ACU- with stage III and IV, 62.6+ACU- with lymph node metastasis on computed tomogram or MRI, 77.9+ACU- with stage I-II disease with lesion size +AD4- or +AD0-4 cm, and 50.3+ACU- with small cell carcinoma or adenocarcinoma. Side effects from concurrent chemoradiation such as nausea, vomiting, and alopecia were present in all 395 cases. Anemia, leukopenia, thrombocytopenia, hepatotoxicity, and nephrotoxicity were observed to varying degrees, but there was no toxic death. This study suggests that cisplatin-based concurrent chemoradiation in treating cervical cancer patients with high risk factors is effective and relatively well tolerated, with acceptable toxicity.

Keyword

Concurrent Chemoradiation; Cervix Neoplasms; Risk Factors; Radiation

MeSH Terms

Adenocarcinoma/radiotherapy
Adenocarcinoma/mortality
Adenocarcinoma/drug therapy
Adult
Aged
Antineoplastic Agents, Combined/therapeutic use+ACo-
Antineoplastic Agents, Combined/adverse effects
Carboplatin/administration +ACY- dosage
Carcinoma, Squamous Cell/radiotherapy
Carcinoma, Squamous Cell/mortality
Carcinoma, Squamous Cell/drug therapy
Cervix Neoplasms/radiotherapy+ACo-
Cervix Neoplasms/mortality
Cervix Neoplasms/drug therapy
Chemotherapy, Adjuvant/adverse effects
Cisplatin/administration +ACY- dosage
Combined Modality Therapy
Comparative Study
Cyclophosphamide/administration +ACY- dosage
Doxorubicin/administration +ACY- dosage
Female
Fluorouracil/administration +ACY- dosage
Gastrointestinal Diseases/etiology
Gastrointestinal Diseases/epidemiology
Hematologic Diseases/etiology
Hematologic Diseases/epidemiology
Hepatitis, Toxic/etiology
Hepatitis, Toxic/epidemiology
Human
Kidney Diseases/epidemiology
Kidney Diseases/chemically induced
Korea/epidemiology
Life Tables
Lymphatic Metastasis
Middle Age
Particle Accelerators
Radiotherapy, High-Energy+ACo-/adverse effects
Retrospective Studies
Risk
Survival Analysis
Treatment Outcome