Korean J Intern Med.  2011 Dec;26(4):463-465. 10.3904/kjim.2011.26.4.463.

Acute Kidney Injury due to Sodium Bromate Intoxication: A Report of Two Cases

• Ryu DH
• Jang KA
• Kim SM
• Park JW
• Do JY
• Yoon KW

• KMID: 1729251
• DOI: http://doi.org/10.3904/kjim.2011.26.4.463

Abstract

Sodium bromate is a strong oxidant used as a neutralizing solution in hair permanents, as well as an auxiliary agent in printing and dyeing. Accidental or deliberate ingestion of bromate solution has rarely been reported in Korea. The clinical manifestations of bromate intoxication are vomiting, diarrhea, central nervous system symptoms, oliguric or non-oliguric acute kidney injury, hemolytic anemia, and deafness; most of these manifestations are reversible, with the exception of renal failure and deafness. Here, we report on two patients who demonstrated distinct clinical progressions. In the first case, a 16-year-old woman was successfully treated with hemodialysis and recovered renal function without hearing loss. However, in the second case, delayed hemodialysis resulted in persistent renal failure and hearing loss in a 77-year-old woman. This suggests that emergency therapeutic measures, including hemodialysis, should be taken as soon as possible, as the rapid removal of bromate may be essential to preventing severe intoxication and its sequelae.

Keyword

Acute kidney injury; Sodium bromate

MeSH Terms

Acute Kidney Injury/*chemically induced/therapy
Adolescent
Aged
Bromates/*toxicity
Fatal Outcome
Female
Hearing Loss
Humans
Kidney Failure, Chronic/*therapy
Renal Dialysis
Sodium Compounds/*toxicity