Korean J Nephrol.  2001 Jul;20(4):732-735.

Bromate Intoxication Associated with Acute Renal Failure

• Song KI
• Kim SH
• Jang JG
• Choi JS

Abstract

Bromate salt is very toxic oxidant. The clinical manifestations of bromate intoxications are vomiting, diarrhea, depression of central nervous system, oliguric or non-oliguric renal failure, hemolytic anemia and deafness. Most of the toxic manifestations are reversible with the exception of renal failure and deafness. Since bromate is a small hydrophilic molecule, its removal by dialysis, especially hemodialysis, can reasonably be expected. Since the serious complications such as deafness, acute renal failure usually occur concurrently within 4-16 hours after ingestion, dialysis should therefore be considered in every patient presenting within a few hours of a significant amount of bromate. Recently, we encountered a 40-year-old female, past hairdresser, who was admitted to Asan Kangnung Hospital due to frequent diarrhea, vomiting and anuria after ingestion of sodium bromate. The patient required regular hemodialysis therapy and has not any evidence of complication such as hearing loss, blindness and irreversible renal failure. The clinician must assess the potential for preventing irreversible ototoxicity and nephrotoxicity and weigh the importance of early intervention against the possible risks of aggressive treatment in bromate intoxication.

Keyword

Bromate intoxication; Acute renal failure

MeSH Terms

Acute Kidney Injury*
Adult
Anemia, Hemolytic
Anuria
Blindness
Central Nervous System
Chungcheongnam-do
Deafness
Depression
Dialysis
Diarrhea
Early Intervention (Education)
Eating
Female
Hearing Loss
Humans
Renal Dialysis
Renal Insufficiency
Sodium
Vomiting
Sodium