Vanishing Pancreatic Grafts
- Affiliations
-
- 1San Diego Microsurgical Institute, USA. msurgical@yahoo.com
- 2Scripps Mercy Hospital, USA.
- 3University of California San Diego Medical Center, USA.
- 4Scripps Clinic, USA.
Abstract
- Comparison of pancreaticoduodenal transplants (PDT) and duct-ligated pancreas transplant (DLPT) were performed using syngeneic and allogeneic studies in rats. Both DLPT and PDT allogeneic grafts showed mild rejection. DLPT groups showed disorganized pathology and acini replaced by fat. Eventually, massive fibrosis was seen in the Islets of Langerhans, as well as rejection cellular infiltrates. In both PDT groups, normal histology was observed in the same period. Thus the effect of duct occlusion is highly detrimental for the grafts.