Yonsei Med J.  2004 Dec;45(6):1169-1172. 10.3349/ymj.2004.45.6.1169.

Vanishing Pancreatic Grafts

Affiliations
  • 1San Diego Microsurgical Institute, USA. msurgical@yahoo.com
  • 2Scripps Mercy Hospital, USA.
  • 3University of California San Diego Medical Center, USA.
  • 4Scripps Clinic, USA.

Abstract

Comparison of pancreaticoduodenal transplants (PDT) and duct-ligated pancreas transplant (DLPT) were performed using syngeneic and allogeneic studies in rats. Both DLPT and PDT allogeneic grafts showed mild rejection. DLPT groups showed disorganized pathology and acini replaced by fat. Eventually, massive fibrosis was seen in the Islets of Langerhans, as well as rejection cellular infiltrates. In both PDT groups, normal histology was observed in the same period. Thus the effect of duct occlusion is highly detrimental for the grafts.

Keyword

Pancreaticoduodenal transplants; duct-ligated pancreas transplants

MeSH Terms

Animals
Graft Rejection/pathology
Ligation/adverse effects
Pancreas/*pathology
Pancreas Transplantation/*adverse effects
Pancreatic Ducts/surgery
Postoperative Period
Rats
Rats, Inbred Lew
Rats, Sprague-Dawley
Research Support, Non-U.S. Gov't
Transplantation, Homologous
Transplantation, Isogeneic
Full Text Links
  • YMJ
Actions
Cited
CITED
export Copy
Close
Share
  • Twitter
  • Facebook
Similar articles
Copyright © 2024 by Korean Association of Medical Journal Editors. All rights reserved.     E-mail: koreamed@kamje.or.kr