Yonsei Med J.
2014 May;55(3):834-837. 10.3349/ymj.2014.55.3.834.
Ibuprofen Associated Acute Vanishing Bile Duct Syndrome and Toxic Epidermal Necrolysis in an Infant
- Affiliations
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- 1Department of Pediatrics, Pusan National University School of Medicine, Yangsan, Korea. jhongpark@pusan.ac.kr
- 2Medical Research Institute, Pusan National University Hospital, Busan, Korea.
- 3Department of Pediatrics, Pusan National University Children's Hospital, Yangsan, Korea.
- KMID: 2068699
- DOI: http://doi.org/10.3349/ymj.2014.55.3.834
Abstract
- Acute vanishing bile duct syndrome, a rare but rapidly progressive destruction of the intrahepatic bile ducts with unknown pathogenesis, is most often a drug- or toxin-related. Toxic epidermal necrolysis is a serious dermatologic condition and a potentially life threatening disease, which is drug or infection induced. Ibuprofen associated acute vanishing bile duct syndrome and toxic epidermal necrolysis have not been reported previously in infants. We report a 7-month-old infant with ibuprofen associated toxic epidermal necrolysis, followed by severe and rapidly progressive vanishing bile duct syndrome. She recovered totally with supportive care.
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