J Korean Pediatr Soc.  2002 Sep;45(9):1146-1149.

A Case of Stevens-Johnson Syndrome Plus Vanishing Bile Duct Syndrome Associated with Ibuprofen Use

• Choi JY
• Kim SY
• Byun SO
• Park JH

Abstract

Acute vanishing bile syndrome is a cause of progressive cholestasis. It is most often drug or toxin related. It's pathogenesis is unknown. Stevens-Johnson syndorme is a well-recognized immune complex-mediated hypersensitivity reaction. It is induced by drug or infection. It has classic systemic, mucosal, and dermatologic manifestations. We report a case of a 14 years old female suffering from Stevens-Johnson syndrome plus vanishing bile duct syndrome associated with ibuprofen use. We report the case with a brief review of its related literature.

Keyword

Vanishing bile duct syndorme; Stevens-Johnson syndrome; Ibuprofen

MeSH Terms

Adolescent
Bile Ducts*
Bile*
Cholestasis
Female
Humans
Hypersensitivity
Ibuprofen*
Stevens-Johnson Syndrome*
Ibuprofen