J Korean Med Sci.  2008 Apr;23(2):278-283. 10.3346/jkms.2008.23.2.278.

Outcomes of a Modified CALGB 19802 Regimen in Adult Acute Lymphoblastic Leukemia

• Han AR
• Kim K
• Jang JH
• Kim WS
• Ahn JS
• Jung CW
• Lee MH
• Kang WK

• KMID: 1713461
• DOI: http://doi.org/10.3346/jkms.2008.23.2.278

Abstract

We analyzed the efficacy and toxicity of a modified Cancer and Leukemia Group B (CALGB) 19802 regimen in adult acute lymphoblastic leukemia (ALL). From February 2002 to August 2005, 25 adults with untreated ALL were enrolled in the study. Compared to the original regimen, the modified CALGB 19802 regimen consisted of a 4-drug induction (cyclophosphamide, daunorubicin, vincristine, and prednisone) instead of a 5-drug induction (L-asparaginase was added to the previous regimen). This was followed by high-dose methotrexate (1,000 mg/m(2)X3 days) and cytarabine (2,000 mg/m(2)X4 days) for the consolidation cycles. High-dose systemic and intrathecal methotrexate was given for central nervous system prophylaxis. Twentythree patients (92%) achieved a complete remission (CR), and two patients (8%) had refractory disease. With a median follow-up of 21.5 months, 10 patients (40%) were alive and continued to be in CR. The 3-yr probability of an event-free survival and the overall survival were 39.0% and 47.4%, respectively. Treatment related mortality and major grade 3 to 4 neurotoxicity occurred in 1 patient and 3 patients, respectively. The modified CALGB 19802 regimen demonstrated a high remission rate and a favorable survival rate.

Keyword

Precursor Cell Lymphoblastic Leukemia-Lymphoma; Drug Therapy

MeSH Terms

Adolescent
Adult
Aged
Antineoplastic Combined Chemotherapy Protocols/*therapeutic use
Cyclophosphamide/*administration & dosage
Daunorubicin/*administration & dosage
Disease-Free Survival
Female
Humans
Male
Middle Aged
Precursor Cell Lymphoblastic Leukemia-Lymphoma/*drug therapy
Prednisone/*administration & dosage
Remission Induction
Treatment Outcome
Vincristine/*administration & dosage

Figure

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  Fig. 1 Kaplan-Meier plots of overall survival.

• 

  Fig. 2 Kaplan-Meier plots of event-free survival.

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