Korean J Radiol.  2014 Feb;15(1):145-150. 10.3348/kjr.2014.15.1.145.

Effect of Imaging Time in the Magnetic Resonance Detection of Intracerebral Metastases Using Single Dose Gadobutrol

• Jeon JY
• Choi JW
• Roh HG
• Moon WJ

• KMID: 1711490
• DOI: http://doi.org/10.3348/kjr.2014.15.1.145

Abstract

OBJECTIVE
To compare the effect of imaging time delay on the MR detection of intracerebral metastases using single dose gadobutrol.
MATERIALS AND METHODS
Twenty-one patients with intracerebral metastases underwent contrast-enhanced MR with three-dimensional T1-weighted sequence at 1 minute, 5 minutes and 10 minutes after a single dose injection of gadobutrol. One hundred index metastatic lesions (1 to 30 mm; median, 7 mm) were chosen for the analysis. For the qualitative analysis, lesion conspicuity were assessed on a 1 (worst) to 5 (best) scale of the index lesions by an expert reader. For the quantitative analysis, signal intensity (SI) of enhancing lesions and normal parenchyma was measured to determine the contrast rate (CR, %) ([postcontrast SI lesion - postcontrast SI white matter] x 100 / postcontrast SI white matter) and the enhancement rate (ER, %) ([postcontrast SI lesion - baseline SI gray matter] x 100 / baseline SI gray matter). Statistical comparisons were made between three different time delays.
RESULTS
Lesion conspicuity did not differ significantly among the three time delays (p = 0.097). Although the SI, CR and ER of lesions did not reveal any significant difference between 1 minute and 5 minutes delayed images, both the 1 minute and 5 minutes delayed images showed significantly higher CRs of lesions compared with the 10 minutes delayed images (p = 0.004 and p = 0.001, respectively).
CONCLUSION
With single dose gadobutrol, imaging time delay did not have an effect on lesion conspicuity. Both 1-minute and 5-minute-delayed imaging after gadobutrol injection appears to be effective for the detection of intracerebral metastases.

Keyword

Intracerebral metastases; Single dose gadobutrol; Gadovist; MRI; Contrast agent

MeSH Terms

Adult
Aged
Aged, 80 and over
Brain Neoplasms/*diagnosis/*secondary
Contrast Media/administration & dosage/*diagnostic use
Female
Humans
Image Enhancement/methods
Magnetic Resonance Imaging/*methods
Male
Middle Aged
Observer Variation
Organometallic Compounds/administration & dosage/*diagnostic use
Time Factors
Contrast Media
Organometallic Compounds

Figure

• 

  Fig. 1 28-year-old woman displaying brain metastases from breast cancer. Axial contrast-enhanced 3D-FSPGR images at 1 minute (A), 5 minutes (B), and 10 minutes (C) after injection of 1.0-mol/L gadobutrol show enhancing brain metastasis, which shows higher contrast enhancement in 1 minute and 5 minutes delayed images than in 10 minutes delayed images (arrows). This lesion in 10 minutes delayed image was missed in initial reading session. Larger enhancing mass shows good contrast enhancement at any time-point. 3D = three-dimensional, FSPGR = fast spoiled gradient echo

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