J Biomed Res.  2014 Jun;15(2):58-61.

Hematologic and hemodynamic findings during hemodialysis in 13 beagle dogs

• Ji CM
• Jung HW
• Jang HM
• Moon JH
• Jung DI

Abstract

Hemodialysis is an effective therapy for renal failure in veterinary practice. To evaluate hematologic and hemodynamic changes during hemodialysis, 13 dogs were treated with hemodialysis, after which complete blood cell counts (CBC), serum chemistry, and mean systolic blood pressure were analyzed. For CBC, white blood cells (WBC) and platelets underwent significant changes. In serum chemistry, there were significant differences in blood urea nitrogen (BUN), creatinine, total protein, albumin, globulin, amylase, calcium, potassium, and phosphorus contents. Further, mean systolic blood pressure suddenly increased in early hemodialysis and decreased significantly thereafter. During hemodialysis, adverse effects were observed in some dogs as follows: bleeding (1 dog), anemia (2 dogs), leukopenia (8 dogs), thrombocytopenia (2 dogs), and hypotension (1 dog). This study demonstrates hematologic and hemodynamic effects during hemodialysis as well as complications similar to human medicine. Before applying the commercialized human hemodialysis system to canine renal failure patients, we monitored hematologic and hemodynamic findings during hemodialysis in healthy beagle dogs.

Keyword

hemodialysis; renal failure; dog

MeSH Terms

Amylases
Anemia
Animals
Blood Cell Count
Blood Pressure
Blood Urea Nitrogen
Calcium
Chemistry
Creatinine
Dogs*
Hemodynamics*
Hemorrhage
Humans
Hypotension
Leukocytes
Leukopenia
Phosphorus
Potassium
Renal Dialysis*
Renal Insufficiency
Thrombocytopenia
Amylases
Calcium
Creatinine
Phosphorus
Potassium