Korean J Dermatol.  1987 Apr;25(2):199-208.

Antibiotic Susceptibility Test of Neisseria gonorrhoeae by Disc Diffusion Method and Its Correlaction with Agar Plate Dilution Method

• Ro YS
• Kim YT
• Kim JH
• Kim JH

Abstract

In this study, we compared the MIC by agar plate dilution method with the inhibition zone diameters by ordinary disc diffusion method and 24 hr-prediffusion disc method on five antibiotics, respectively. The results were summarized as follows; 1. The agar plate dilution method and the ordinary disc diffusion method gave a satisfactory degree of correlation by linear regression. The correlation coeffecients were highly significant for penicillin (r= -0.88) and ampicillin(r = -0.91) but less significant for tetracyclin(r= -0.34), kanamycin(r= -0.55) and spectinomycin (r = -0.46). 2. Between the agar plate dilution method and the 24 hour-prediffusion disc method the correlation coeffecients were highly significant for penicillin(r= -0.9) and ampicillin (r= -0.91) but less so for tetracyclin(r= -0.4), kanamycin (r=-0.57) and spectinomycin(r=-0.5), 3. In relation to the MIC values by agar pate dilution method, the correlation coefficients were slightly higher and the slopes of linear regression were steeper for the 24 hour-prediffusion disc method than the ordinary disc diffusion method, but the differences were statistically not significant.

Keyword

Agar plate dilution; Disc diffusion method; 24 hour - Prediffusion disc method; Correlation coefficients; Neisseria gonorrhoeae

MeSH Terms

Agar*
Ampicillin
Anti-Bacterial Agents
Diffusion*
Kanamycin
Linear Models
Neisseria gonorrhoeae*
Neisseria*
Penicillins
Spectinomycin
Agar
Ampicillin
Anti-Bacterial Agents
Kanamycin
Penicillins
Spectinomycin