Korean Circ J.  1979 Jun;9(1):17-22. 10.4070/kcj.1979.9.1.17.

A Clinical Study on Coenzyme Q10(Neuquinon(R)) in the Treatment of Congestive Heart Failure

• Kim JH
• Lim JY
• Choi YS
• Seo JD
• Lee YW

• KMID: 1677232
• DOI: http://doi.org/10.4070/kcj.1979.9.1.17

Abstract

Coenzyme Q is concentrated in Golgi apparatus membranes and mitochondria, but not in other membranes. Although it is difficult to prove the metabolic action of coenzyme Q administered exogenously in clinical cases, the effect of this substance can be evaluated by criteria based on clinical findings. In an attempt to evaluate the effect of coenzyme Q for the treatment of 67 patients(male 26 cases, female 41 cases) of congestive heart failure, we administered Coenzyme Q1030mg daily for 4 to 8 weeks. Most of them were valvular heart disease(74.6%) and hypertension (14.9%). Clinical effects were evaluated at least 4 weeks later by the criteria using a scoring method of severity of congestive heart failure which was devised by Ishiyama, etc. In summary, a definite effect was found in 13 cases(19%) and a mild effect was observed in 46 cases(69%). During treatment there were no significant side effects, and also no significant changes in heart rate and blood pressure.

MeSH Terms

Blood Pressure
Estrogens, Conjugated (USP)*
Female
Golgi Apparatus
Heart
Heart Failure*
Heart Rate
Humans
Hypertension
Membranes
Mitochondria
Research Design
Ubiquinone
Estrogens, Conjugated (USP)
Ubiquinone