Clinical Significance of Human Papillomavirus Infection and Epidermal Growth Factor Receptor in Cervical Carcinoma

Kang, Soon Beom; Park, Chang Soo; Jeon, Hye Won; Kim, Jong Hoon; Park, Noh Hyun; Song, Yong Sang; Lee, Hyo Pyo

Abstract

Carcinoma of uterine cervix is the most common malignant tumor in Korean women but the pathogeneeis of that is not well known. Recently human papillomavirus(HPV), especially type 16 and 18, ras and c-erb-B oncogenes and epiderma1 growth factor receptor(EGFR) have been knuwn to be implicated in the oncogenesis of cervical carcinoma. Fifty two women treated for invasive squamous cell carcinoma of uterine cervix and thirty three nomal controls were studiel to inveatigate the role of the infection of HPV type 16, 18 and the expression of EGFR in tumorigenesis and progression of cnvical cancer and to inveatigate the correlation behveen the infection of HPV and the exprression of EGFR in cervical cancer. The presence of HPV DNA was analysed using HPV amplification by polymerase chain reaction(PCR), abd tge expression of EGFR by immunohistochemical staining. The HPV 16/18 DNA were detected in 40 of 52(76.9%) cervical cancer tissue while in 6 of 33(18.2%) control tissues(p<0.05). The expression of EGFR was positive in 27 of 52(51.9%) cervical cancer while in none of control tissues (p<0.05%). The infection of HPV 16/18 and expression of EGFR were not significantly associatxl with the age, stage, histologic type., lymph nuxle metastases, tumor size, incasive depth of cervical wall and 5-year survival reate. Tere was no significant correlation between HPV positivity and EGFR expression in cervical cancer patients. These data suggest that HPV infection and EGRF expression might play a role in carcinogenesis but not in the progression of metastasis of cervical cancer.