J Korean Neurosurg Soc.  1990 Feb;19(2):217-224.

The Combined Therapeutic Effect of Drugs in Experimental Acute Focal Cerebral Ischemia

• Yoo DJ
• Shin KM
• Han JS

Abstract

The study was designed to examine the effects of pretreatment with mannitol, methyl prednisolone and nimodipine on the acute focal cerebral ischemia in the cats of occlusion of the proximal part of the middle cerebral artery via the postorbital approach. The energy metabolisms of the brain was measured utilizing the high liquid performance chromatography in the brain tissues of cats. The experimental animals were seperated into 3 groups. group I: the sham control group. group II: the recirculation group. group III: the treatment group. There were significant increase in the ATP, GTP, UTP and E.C. levels in focal ischemic cerebral tissues of the treatment group when compared with the recirculation group. It is suggested that pretreatment with the combination of these drugs may prevent the ischemic damage from the acute focal cerebral ischemia by the maintenance of high energy metabolites. However further studies should determine the synergistic pharmacologic mechanisms in this therapeutic strategy.

MeSH Terms

Adenosine Triphosphate
Animals
Brain
Brain Ischemia*
Cats
Chromatography
Energy Metabolism
Guanosine Triphosphate
Mannitol
Middle Cerebral Artery
Nimodipine
Prednisolone
Uridine Triphosphate
Adenosine Triphosphate
Guanosine Triphosphate
Mannitol
Nimodipine
Prednisolone
Uridine Triphosphate