Korean J Hematol.  2004 Sep;39(3):172-176.

A Case of Low Grade MALT Lymphoma in the Mediastinum with Clinical Appearance of Waldenstr m's Macroglobulinemia

• Joo YD
• Lee WS
• Kim YJ
• Kim KH
• Park BM
• Kwon MJ
• Kim AR
• Kim CH
• Sohn CH

Abstract

Low-grade B cell mucosa-associated lymphoid tissue (MALT) lymphoma makes up 8% of non-Hodgkin's lymphomas. It has been characterized by a prolonged clinical course and persistent disease at the site of origin. Most patients with low-grade B cell MALT lymphoma occur in the stomach, orbit, intestine, lung, thyroid, salivary gland, skin, soft tissues, bladder, kidney, and central nervous system. The diagnosis of MALT lymphoma can be established by a characteristic finding of infiltration of small lymphocytes that are monoclonal B cell and CD5 negative. Bone marrow involvement seems uncommom but has been developed. Waldenstr m's macroglobulinemia (WM) is usually defined as bone marrow infiltration of lymphoplasmacytoid lymphocytes with a high level of circulating macroglobulin IgM. Lymphadenopathy and splenomegaly occurs in 20~40% of WM. It is very hard work to do differential diagnosis between disseminated low-grade B cell MALT lymphoma and WM with organ involvement by a bone marrow examination. We reprot one case of low grade mediastinal MALT lymphoma with bone marrow involvement and a high level of serum monoclonal IgM with clinical appearance of WM.

Keyword

Low-grade B cell MALT lymphoma; Mediastinum; Waldenstrom's macroglobulinemia

MeSH Terms

Bone Marrow
Bone Marrow Examination
Central Nervous System
Diagnosis
Diagnosis, Differential
Humans
Immunoglobulin M
Intestines
Kidney
Lung
Lymphatic Diseases
Lymphocytes
Lymphoid Tissue
Lymphoma
Lymphoma, B-Cell, Marginal Zone*
Lymphoma, Non-Hodgkin
Mediastinum*
Orbit
Salivary Glands
Skin
Splenomegaly
Stomach
Thyroid Gland
Urinary Bladder
Waldenstrom Macroglobulinemia*
Immunoglobulin M