Korean J Psychopharmacol.  2002 Sep;13(3):148-153.

Neutropenia in Psychiatric Out-Patients

• Baik HC
• Yoon DJ
• Yoon HJ
• Bahn GH

Abstract

OBJECT: The study was performed to examine the psychotrophic drugs used in psychiatric out-patients in which neutropenia developed and current state of consultation and to confirm the importance of complete blood count and differential count (CBC/DC).
SUBJECTS AND METHODS
The subjects were 60 patients of our university hospital in which neutropenia developed in out-patient department (OPD) of psychiatry during recent three years. The absolute neutrophil counts of patient were below 2,000/mm3.
RESULTS
The reasons why exam was performed were mainly to follow-up exam during medications. Mood stabilizers such as carbamazepine, phenytoin, sodium valproate were identified to cause neutropenia in the group using multiple drugs, and clozapine was highly related in the group using single drug. But many kinds of drugs were related with neutropenia. We have not checked well enough the CBC/DC and have not consulted well to hematologist in OPD of neuropsychiatry.
CONCLUSIONS
It is important to find neutropenia in the psychiatric out-patients using psychotropic drugs. We had better check CBC/DC routinely and consult to hematologist.

Keyword

Neutropenia; Psychotrophic drug; Psychiatric out-patient; CBC/DC

MeSH Terms

Blood Cell Count
Carbamazepine
Clozapine
Follow-Up Studies
Humans
Neuropsychiatry
Neutropenia*
Neutrophils
Outpatients*
Phenytoin
Psychotropic Drugs
Valproic Acid
Carbamazepine
Clozapine
Phenytoin
Psychotropic Drugs
Valproic Acid