Korean J Physiol Pharmacol.
2004 Dec;8(6):351-354.
Cytotoxicological Effect of Tebufenozide, an Insect Growth Regulator (IGR) : Stimulation of Filamentous Actin Reorganization and Enhancement of Hsp27 Expression in Drosophila Kc Cells
- Affiliations
-
- 1Department of Pharmacology, Medical Research Center (MRC), Kyung Hee University School of Medicine, Seoul 130-701, Korea. dream21@khu.ac.kr
Abstract
- The cytotoxicological responses to insect growth regulator (IGR), using tebufenozide as ecdysteroid mimic, were investigated in Drosophila Kc cells. Treatment of Kc cells with tebufenozide showed significant growth inhibition and striking morphological changes including aggregation and elongation of the cells. In order to understand the cellular mechanism underlying the response of Drosophila cells to tebufenozide, immunofluorescence microscopy was performed. We found that treatment of Kc cells with tebufenozide enhanced the reorganization of f-actin and stimulated the expression of hsp27. These data suggest a possible association of filamentous actin (f-actin) and hsp27 in the cytotoxicological mechanisms of growth regulators in Drosophila cells.
Keyword
- Full Text Links
-
- Actions
-
Cited
- CITED
-
- Close
- Share
-
- Similar articles
-
- Expression of Heat Shock Protein 27 and Apoptosis in Renal Cell Carcinomas
- Characterization of the Rho GTPase-Activating Protein RhoGAP68F
- Protein Expression of the Bombyx mori Decapentaplegic Gene using the Baculovirus Expression Vector System
- Filamentous Fungi Isolated from Platypus koryoensis, the Insect Vector of Oak Wilt Disease in Korea
- Silencing of Heat Shock Protein 27 Expression Accelerates Doxazosin-induced Apoptosis in Prostate Cancer Cell Line PC-3
