Korean J Clin Microbiol.  2003 Mar;6(1):47-51.

Antibiogram of Escherichia coli and Klebsiella spp. Detected by Vitek ESBL Test

• Cho EH
• Lee NY

Abstract

BACKGROUND: Extended-spectrum beta -lactamase (ESBL) producing Escherichia coli and Klebsiella spp. isolates are clinically resistant to all the beta -lactams except carapenems and cephamycins. This study was to determine the prevalence of ESBL producing E. coli and Klebsiella spp. and the rates and trends of resistance to extended-spectrum beta -lactams and other antimicrobial agents in ESBL producing E. coli and Klebsiella spp..
METHODS
During the periods of 2002, a total 2,551 clinical isolates of E. coli & Klebsiella spp. were collected from patients of the Samsung medical center, Seoul, Korea. Antimicrobial susceptibility test and determination of ESBL production were performed by Vitek GNS-433 card.
RESULTS
151/1,594 (9.5%) of E. coli isolates, 128/896 (14.3%) of K. pneumoniae isolates and 11/61 (18.0%) of K. oxytica were ESBL producing strains. Resistance to cefoxitin and cefepime were 2.4% and 13.4% in ESBL producing isolates. Imipenem had excellent activity against E .coli and Klebsiella spp. (100% susceptible).
CONCLUSION
In this study, ESBL-producing E. coli and Klebsiella spp were more resistant to beta -lactams including cefepime than ESBL non-producing E. coli and Klebsiella spp.. ESBL producing E. coli and Klebsiella spp. showed a high level of co-resistance with aminoglycosides and fluoroquinolones. Imipenem showed the highest level of activity against E. coli and Klebsiella spp..

Keyword

Vitel GNS 433 Card; ESBL; Cefepime; Cefoxitin; Imipenem

MeSH Terms

Aminoglycosides
Anti-Infective Agents
Cefoxitin
Cephamycins
Escherichia coli*
Escherichia*
Fluoroquinolones
Humans
Imipenem
Klebsiella*
Korea
Microbial Sensitivity Tests*
Pneumonia
Prevalence
Seoul
Aminoglycosides
Anti-Infective Agents
Cefoxitin
Cephamycins
Fluoroquinolones
Imipenem