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Clinical and Microbiologic Efficacy and Safety of Imipenem/Cilastatin/ Relebactam in Complicated Infections: A Meta-analysis

Sahra S, Jahangir A, Hamadi R, Jahangir A, Glaser A

Background: Antimicrobial resistance is on the rise. The use of redundant and inappropriate antibiotics is contributing to recurrent infections and resistance. Newer antibiotics with more robust coverage for Gram-negative bacteria...
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Signal Detection of Imipenem Compared to Other Drugs from Korea Adverse Event Reporting System Database

Park K, Soukavong , Kim J, Kwon KE, Jin XM, Lee J, Yang BR, Park BJ

PURPOSE: To detect signals of adverse drug events after imipenem treatment using the Korea Institute of Drug Safety & Risk Management-Korea adverse event reporting system database (KIDS-KD). MATERIALS AND METHODS: We...
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Multicenter Study of Antimicrobial Susceptibility of Anaerobic Bacteria in Korea in 2012

Lee Y, Park YJ, Kim MN, Uh Y, Kim MS, Lee K

BACKGROUND: Periodic monitoring of regional or institutional resistance trends of clinically important anaerobic bacteria is recommended, because the resistance of anaerobic pathogens to antimicrobial drugs and inappropriate therapy are associated...
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Molecular Characteristics of blaOXA-23-Producing Acinetobacter baumannii Isolated from a University Hospital

Jang IH, Park SD, Uh Y, Lee GS, Kim JB, Choi I

BACKGROUND: Multi-drug resistant (MDR) Acinetobacter baumannii has emerged as a significant infectious agent in hospitals worldwide. The purpose of this study was to determine the molecular characterization of MDR A....
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Correlation between Carbapenem Prescription Trends and Imipenem Resistance in Acinetobacter baumannii at an Intensive Care Unit between 2006 and 2010

Hong SK, Seong MW, Lee DH, Kim EC

  • KMID: 2312212
  • Lab Med Online.
  • 2012 Oct;2(4):232-234.
Carbapenem resistance in Acinetobacter baumannii has increased rapidly worldwide. It is generally assumed that carbapenem prescription in a hospital has a significant impact on imipenem resistance in A. baumannii. However,...
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Further Increases in Carbapenem-, Amikacin-, and Fluoroquinolone-Resistant Isolates of Acinetobacter spp. and P. aeruginosa in Korea: KONSAR Study 2009

Lee K, Kim MN, Kim JS, Hong HL, Kang JO, Shin JH, Park YJ, Yong D, Jeong SH, Chong Y, The KONSAR Group

PURPOSE: The increasing prevalence of antimicrobial resistant bacteria has become a serious worldwide problem. The aim of this study was to analyze antimicrobial resistance data generated in 2009 by hospitals...
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Increase of Ceftazidime- and Fluoroquinolone-Resistant Klebsiella pneumoniae and Imipenem-Resistant Acinetobacter spp. in Korea: Analysis of KONSAR Study Data from 2005 and 2007

Lee K, Lee MA, Lee CH, Lee J, Roh KH, Kim S, Kim JJ, Koh E, Yong D, Chong Y, KONSAR Group

PURPOSE: Antimicrobial resistance monitoring could be a useful source of information for treating and controlling nosocomial infections. We analyzed antimicrobial resistance data generated by Korean Hospitals and by a commercial...
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Outbreaks of Imipenem Resistant Acinetobacter Baumannii Producing OXA-23 beta-Lactamase in a Tertiary Care Hospital in Korea

Yang HY, Lee HJ, Suh JT, Lee KM

PURPOSE: Since November 2006, imipenem-resistant Acinetobacter baumannii isolates have increased in Kyung Hee University Hospital in Seoul, Korea. The purpose of this study was to determine the genetic basis and...
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Imipenem-Resistant Pseudomonas aeruginosa : Risk Factors for Nosocomial Infections

Onguru P, Erbay A, Bodur H, Baran G, Akinci E, Balaban N, Cevik MA

The aim of this study was to determine the risk factors for nosocomial infections of imipenem-resistant Pseudomonas aeruginosa (IRPA). A prospective case-control study was performed at a tertiary care hospital...
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In vitro Antimicrobial Synergy against Imipenem-Resistant Acinetobacter baumannii

Sung H, Choi SJ, Yoo S, Kim MN

BACKGROUND: Most imipenem-resistant Acinetobacter baumannii (IRAB) isolates are multiresistant, leaving few options for an effective antimicrobial therapy. We purposed to select possible candidates for the combinations of antimicrobials that...
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Prevalence of Carbapenemase and Integrase Genes in Imipenem-resistant Acinetobacter baumannii and Pseudomonas aeruginosa Collected over Several Years in a University Hospital

Oh HR, Jang SJ, Yu FN, Park G, Li XM, Shin SH, Kim WY, Moon DS, Park YJ

  • KMID: 2300457
  • Korean J Clin Microbiol.
  • 2007 Oct;10(2):128-134.
BACKGROUND: The incidence of infections with imipenem- resistant Acinetobacter baumannii (IRAB) and Pseudomonas aeruginosa (IRPA) is increasing worldwide, and recent molecular studies indicate that the prevalence of carbapenemases is increasing...
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Seven Cases of Decreased Serum Valproic Acid Concentration During Concomitant Use of Carbapenem Antibiotics

Lee SG, Kim JH, Joo JY, Kwon OH

Valproic acid (VPA) is a commonly prescribed anticonvulsant drug for the treatment of various forms of epilepsy. Concomitant administration of VPA and carbapenem antibiotics such as panipenem/ betamipron and meropenem...
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Comparison of Efficacy of Cefoperazone/Sulbactam and Imipenem/Cilastatin for Treatment of Acinetobacter Bacteremia

Choi JY, Kim CO, Park YS, Yoon HJ, Shin SY, Kim YK, Kim MS, Kim YA, Song YG, Yong D, Lee K, Kim JM

Multiple antibiotic reisistance threatens successful treatment of Acinetobacter baumannii infections worldwide. Increasing interest in the well-known activity of sulbactam against the genus Acinetobacter has been aroused. The purpose of this...
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Further Increase of Vancomycin-Resistant Enterococcus faecium, Amikacin- and Fluoroquinolone-Resistant Klebsiella pneumoniae, and Imipenem-Resistant Acinetobacter spp. in Korea: 2003 KONSAR Surveillance

Lee K, Park KH, Jeong SH, Lim HS, Shin JH, Yong D, Ha GY, Chong Y, KONSAR Group

Monitoring temporal trends of antimicrobial resistance can provide useful information for the empirical selection of antimicrobial agents to treat infected patients and for the control of nosocomial infections. In this...
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Status of Nosocomial Urinary Tract Infections in the ICU: Molecular Epidemiology of Imipenem Resistant P. aeruginosa

Yu SM, Jeon SS, Kang IS, An HG

  • KMID: 810623
  • J Korean Acad Nurs.
  • 2006 Dec;36(7):1204-1214.
PURPOSE: This retrospective study was done to evaluate the status of nosocomial urinary tract infections and to determine the risk factors andtransmission route of causal IRPA through molecular epidemiology....
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High Prevalence of Ceftazidime-Resistant Klebsiella pneumoniae and Increase of Imipenem-Resistant Pseudomonas aeruginosa and Acinetobacter spp. in Korea: a KONSAR Program in 2004

Lee K, Lim CH, Cho JH, Lee WG, Uh Y, Kim HJ, Yong D, Chong Y

A nationwide antimicrobial resistance surveillance has been conducted since 1997 in Korea. In this study, susceptibility test data generated in 2004 by KONSAR group hospitals were analyzed and compared to...
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Prevalence of Imipenem-Resistant Pseudomonas aeruginosa Isolates and Mechanisms of Resistance

Yoon WS, Lee BY, Bae IK, Kwon SB, Jeong SH, Jeong TJ, Jung YW

  • KMID: 2224689
  • Korean J Clin Microbiol.
  • 2005 Apr;8(1):26-33.
BACKGROUND: Spread of imipenem-resistant Pseudomonas aeruginosa isolates is an important clinical threat. The aim of this study is to survey the prevalence of carbapenem-resistant P.aeruginosa isolates in a university hospital,...
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Molecular Epidemiology of Infection Caused by OXA-23 or IMP-1 beta-Lactamase-Producing Acinetobacter baumannii

Park KO, Son HC, Bae IK, Jeong SH

  • KMID: 2224703
  • Korean J Clin Microbiol.
  • 2005 Oct;8(2):121-129.
BACKGROUND: The purposes of this study were to investigate the prevalence of imipenem-resistant clinical Acinetobacter baumannii isolates and to determine the mechanism of the resistance. METHODS: During the period of June...
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Prevalence of OXA-23 Extended-Spectrum beta-Lactamase-Producing Clinical Isolates of Acinetobacter baumannii in a University Hospital, Busan, Korea

Jeon BC, Kwon KY, Jeong SH, Bae IK, Kwon SB, Cho BK, Yong D, Lee K

  • KMID: 1892729
  • Korean J Clin Microbiol.
  • 2004 Sep;7(2):139-147.
BACKGROUND: Acinetobacter baumannii is a glucose-nonfermenting gram-negative rod and is a well-recognized nosocomial pathogen. In recent years, A. baumannii strains showing resistance to carbapenems by producing metallo-beta-lactamases or OXA-type beta-lactamases...
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Efficacy of Panipenem versus Imipenem against Clinical Isolate of Pseudomonas aeruginosa in a Two-Compartment Artificial Capillary Model

Lee DG, Chun HS, Choi SM, Choi JH, Yoo JH, Shin WS

  • KMID: 2285121
  • Infect Chemother.
  • 2004 Aug;36(4):227-233.
BACKGROUND: Panipenem (PAPM) is a new carbapenem which has an enhanced broad spectrum activity against both gram-positive and negative organisms. However, its activities in vitro against Pseudomonas aeruginosa are still...
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