Korean J Clin Microbiol.
2003 Mar;6(1):29-36.
Antimicrobial Resistance of Clinically Important Bacteria Isolated from Hospitals Located in Representative Provinces of Korea
- Affiliations
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- 1Department of Laboratory Medicine, Colleage of Medicine, Pochon CHA University, Korea.
- 2Department of Laboratory Medicine, Yonsei University Colleage of Medicine, Korea. leekcp@yumc.yonsei.ac.kr
- 3Department of Laboratory Medicine, Seoul National University Colleage of Medicine, Korea.
- 4Department of Laboratory Medicine, Ajou University of Medicine, Korea.
- 5Department of Laboratory Medicine, Colleage of Medicine Kosin University, Korea.
- 6Department of Laboratory Medicine, Hanllym University Colleage of Medicine, Korea.
- 7Department of Laboratory Medicine, The Catholic University of Korean, Korea.
- 8Department of Laboratory Medicine, University of Ulsan Medicine Colleage and Asan Medicine Center, Korea.
- 9Department of Laboratory Medicine, Yonsei University Wonju Colleage of Medicine, Korea.
- 10Department of Laboratory Medicine, Chonnam National University Medicine School, Korea.
- 11Department of Laboratory Medicine, Keonyang University Medicine Colleage, Korea.
- 12Department of Laboratory Medicine, Sooncheonhyang University Colleage of Medicine, Korea.
- 13Neodin Medicine Research Center, Korea.
Abstract
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BACKGROUND: A rapid increase of antimicrobial-resistant bacteria has become a serious problem in many countries. The aim of this study was to determine the prevalence of resistance among frequently isolated gram-positive and -negative bacteria in Korea.
METHODS
Data of routine antimicrobial susceptibility test for medically important bacteria, isolated during 3 months of 2002, were collected from 12 university and 1 commercial laboratories in Korea.
RESULTS
The proportions of methicillin-resistant Staphylococcus aureus (MRSA) were 60-88%, but vancomycin-resistant S. aureus was not detected. Among the Enterococcus faecium isolates, the resistance rate to vancomycin was 29%. The resistance rates of Escherichia coli and Klebsiella pneumoniae: 11% and 24% to cefotaxime, respectively, and 12% and 21% to cefoxitin, respectively. The resistance rates of Citrobacter freundii, Enterobacter cloacae, and Serratia marcescens: 28%, 34% and 21% to cefotaxime, respectively, <1%, 8% and 14% to cefepime, respectively. The resistance rates of Acinetobacter baumannii and Pseudomonas aeruginosa were: 65% and 37% to piperacillin, 64% and 19% to ceftazidime, 13% and 20% to imipenem, respectively. The resistant rates varied according to the hospital size. The resistance rates were generally higher among the isolates in the hospitals with more than 1,000 beds. The rates of penicillin-nonsusceptible Streptococcus pneumoniae were 58-90%. Among the Haemophilus influenzae isolates, 55-68% were resistant to ampicillin.
CONCLUSIONS
Antimicrobial resistant strains were prevalent among the medically important clinical isolates, especially, MRSA, vancomycin-resistant enterococci, extended-spectrum -lactamase- or AmpC -lactamase-producing E. coli and K. pneumoniae, third generation cephalosporin-resistant C. freundii, E. cloacae and S. marcescens, imipenem-resistant A. baumannii and P. aeruginosa, penicillin-nonsusceptible S. pneumoniae and ampicillin-resistant H. influenzae. The antimicrobial resistance has become a serious problem in Korea.
Keyword
MeSH Terms
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Acinetobacter baumannii
Ampicillin
Bacteria*
Cefotaxime
Cefoxitin
Ceftazidime
Citrobacter freundii
Cloaca
Enterobacter cloacae
Enterococcus faecium
Escherichia coli
Haemophilus influenzae
Health Facility Size
Imipenem
Influenza, Human
Klebsiella pneumoniae
Korea*
Methicillin-Resistant Staphylococcus aureus
Piperacillin
Pneumonia
Prevalence
Pseudomonas aeruginosa
Serratia marcescens
Streptococcus pneumoniae
Vancomycin
Ampicillin
Cefotaxime
Cefoxitin
Ceftazidime
Imipenem
Piperacillin
Vancomycin
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