J Korean Pediatr Soc.  2003 Sep;46(9):846-853.

Serotypes and Penicillin Susceptibility of Streptococcus pneumoniae Isolated from Clinical Specimens and Healthy Carriers of Korean Children

• Lee JA
• Kim NH
• Kim DH
• Park KW
• Kim YK
• Kim KH
• Park JY
• Choi EH
• Lee HJ

Abstract

PURPOSE
Pneumoccocus is one of the most important causes of invasive infection through the childhood period and the prevelance of antibiotics resistance of pneumococcus is increasing worldwide. A 7-valent conjugate vaccine has been developed. It is important to know the prevalence of each serotype of pneumococci in the countries where the vaccine is used to estimate the coverage rate by the vaccine.
METHODS
One hundred and twenty seven strains of clinical isolates and 72 strains from healthy carriers recovered from Korean children during the period from 1997 to 2002 were subjected to determination of serotype by Quellung reaction and penicillin susceptibility with oxacillin disc diffusion test.
RESULTS
Forty-three per cent of clinical isolates were obtained from children under two years of age. Thirty strains(24%) were isolated from normally sterile body fluids. The frequent serotypes were 19F, 19A, 23F, 6A, 6B and 9V. Fifty-six per cent of the clinical isolates were represented in the current 7-valent protein conjugate pneumococccal vaccine, and 84% when the cross-reactive serotypes were included. Frequent serotypes of strains isolated from one to five year-old healthy children were 19F, 14, 11A, 23F, 18C, and 19A. Seventy-one per cent of the carrier strains were included in the 7-valent vaccine. Ninety-three per cent of the clinical isolates and 86% of carrier strains were not susceptible to penicilline.
CONCLUSION
Fifty-six to 84% of pneumococci recovered from Korean children are covered by the current 7-valent protein conjugate pneumococcal vaccine and the prevalence of penicillin resistance was very high.

Keyword

Streptococcus pneumoniae; Quellung reaction; Conjugate vaccine

MeSH Terms

Anti-Bacterial Agents
Body Fluids
Child*
Diffusion
Humans
Oxacillin
Penicillin Resistance
Penicillins*
Prevalence
Streptococcus pneumoniae*
Streptococcus*
Anti-Bacterial Agents
Oxacillin
Penicillins