J Korean Pediatr Soc.  2003 Aug;46(8):817-820.

Alteration of Biochemical Profiles after High-Dose Intravenous Immunoglobulin Administration in Kawasaki Disease

• Lee JW
• Lee KY

Abstract

PURPOSE
Intravenous immunoglobulin(IVIG) has been used as an immunomodulatory treatment for several immune-mediated diseases. The early effect of high-dose IVIG on biochemical profiles including lipids and proteins was evaluated in patients with Kawasaki disease(KD).
METHODS
Twelve children with KD(nine boys) were treated with IVIG of 2 g/kg over 12 hours. Serial sera were collected from the patients four times: before IVIG treatment and two hours, 24 hours and seven days after IVIG treatment. The samples were frozen at -20 degrees C before biochemical analysis.
RESULTS
A significant decrease in albumin concentration was found two hours h and 24 hours after IVIG treatment, but this recovered to the pretreatment level after seven days. Total cholesterol and triglyceride increased slightly after seven day. A significant decrease in HDL-cholesterol and C- reactive protein was seen two hours and 24 hours after IVIG treatment.
CONCLUSION
High-dose IVIG affects immediate changes in protein profiles and HDL-cholesterol in KD. Changes in HDL-cholesterol induced by IVIG may be the result of changes in systemic protein metabolism.

Keyword

Intravenous immunoglobulin; Kawasaki disease; Proteins; Lipids; HDL-cholesterol

MeSH Terms

Child
Cholesterol
Humans
Immunoglobulins*
Immunoglobulins, Intravenous
Metabolism
Mucocutaneous Lymph Node Syndrome*
Triglycerides
Cholesterol
Immunoglobulins
Immunoglobulins, Intravenous