Korean J Obstet Gynecol.
2005 Jun;48(6):1484-1489.
CYP1A1 Gene Polymorphism in Korean Women with Endometriosis
- Affiliations
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- 1Department of Obstetrics and Gynecology, Seoul National University College of Medicine, Korea. ymchoi@snu.ac.kr
- 2Institute of Reproductive Medicine and Population, Medical Research Center, Seoul National University College of Medicine, Korea.
- 3Department of Pathology, Seoul National University College of Medicine, Korea.
- 4Department of Obstetrics and Gynecology, Kyungpook National University School of Medicine, Korea.
Abstract
OBJECTIVE
To explore the association of the CYP 1A1 gene polymorphism with the risk of endometriosis in a Korean population. DESIGN: Case-control study
METHODS
Two-hundred fifty two Korean women with surgically or histologically diagnosed endometriosis of stage I-IV (ASRM, 1997) were recruited, and 203 women with no evidence of endometriosis served as controls. CYP1A1 gene MspI polymorphism was analyzed by polymerase chain reaction (PCR) and restriction fragment length polymorphism analysis.
RESULTS
There was no significant difference in the genotype or allele distribution of CYP1A1 gene polymorphism between patients with endometriosis and controls. And when classified by stage, there was also no significant difference in the genotype and allele distribution of CYP1A1 gene MspI polymorphism between patients with stage I-II or stage III-IV endometriosis and controls.
CONCLUSION
These results suggest that CYP1A1 gene MspI polymorphism is not associated with the risk of endometriosis in the Korean women.
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