Korean Lepr Bull.  2000 Dec;33(2):47-54.

Interferon-gamma (IFN-gamma) increases CD1 expression through inhibition of IL-10 secretion from M.leprae-infected macrophages of lepromatous leprosy

• Lee SB
• Kim SK
• Lee HJ
• Shin HK
• Kim JP
• Ko YH
• Kim SH
• Chae GT

Abstract

The CD1 system is a novel antigen-presenting system for T cell recognition of lipid and glycolipids in antimicrobial immunity. Lepromatous leprosy is characterized by lack of cell-mediated immunity against M.leprae. The lack of cell-mediated immunity in lepromatous leprosy has been suggested to be correlated with weak CD1 expression on antigen presenting cells. In order to define how CD1 is down-regulated on M. leprae-infected antigen-presenting cells, we examined effects of interferon-gamma(IFN-gamma) on interleukin-10 (IL-10) secretion and CD1 expression of M.leprae-infected macrophages from granuloma of lepromatous leprosy. Our results showed that a significant trend of increased CD1 expression in response to decresed IL-10 secretion from M.leprae-infected macrophages by IFN-gamma. These results suggest that the local cytokine milieu, especially the balance between IFN-gamma and IL-10, is an important determinant in the regulation of CD1 in lepromatous lesions.

Keyword

Leprosy; Macrophage; CD1; IFN-gamma; IL-10

MeSH Terms

Antigen-Presenting Cells
Glycolipids
Granuloma
Immunity, Cellular
Interferon-gamma*
Interleukin-10*
Leprosy
Leprosy, Lepromatous*
Macrophages*
Glycolipids
Interferon-gamma
Interleukin-10