Korean J Anat.  2005 Apr;38(2):133-143.

Experimental Studies on the Factors Related to Hair Loss in Spontaneous Hair Loss C57BL/6N Mice Models

• Kim YI
• Lee MW
• Kwon J
• Song CH
• Lee CH

Abstract

In spontaneous hair loss of C57BL/6N mice model, we investiged the factors related to hair loss by microscopic and immunocytochemical methods. The results were as follows; Microsopic observation of sebaceous gland was developed, and subcutaneous layer was thin in SA and AU group. Number of mast cells in SA and AU group was more increased than that of other groups. Number and immunoreactive density of CD4/CD8 lymphocytes was more increased than that of other groups. Immunoreactivity of substance P and CRF was weakly stained in stem cell region of SA and AU group. Immunoreactivity of CRF-R and CRF-BP was weakly stained in stem cell and bulge regions of SA and AU group. Immunoreactivity of stem cell factor was weakly stained in stem cell, bulge region and dermal papilla of SA and AU group. These experiment suggest that factors related to hair loss in spontaneous hair loss C57BL/6N mice models are increased of mast cell, CD4 and CD8 lymphocytes, and decreased of cytokine and neuropeptide in stem cell, bulge region and dermal papilla.

Keyword

Spontaneous hair loss; Mast cells; Substance P; CRF; CRF-R; CRF-BP; CD4; CD8

MeSH Terms

Animals
Hair*
Lymphocytes
Mast Cells
Mice*
Neuropeptides
Sebaceous Glands
Stem Cell Factor
Stem Cells
Substance P
Neuropeptides
Stem Cell Factor
Substance P