Korean J Otolaryngol-Head Neck Surg.
1997 Sep;40(9):1239-1243.
Distribution of Calcitonin Gene-Related Peptide Immunoreactive Nerve Fibers in Rat Cochlea and Brainstem Auditory Nuclei
- Affiliations
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- 1Department of Otolaryngology-Head and Neck Surgery, College of Medicine, Korea University, Seoul, Korea.
Abstract
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BACKGROUND: Calcitonin gene-related peptide(CGRP) is one of the neuronal elements of the inner ear. CGRP immunoreactive fibers are known to regulate auditory action potential and blood flow of cochlea.
OBJECTIVES
This study was designed to localize the CGRP immunoreactive fibers in the cochlear tissue and auditory brainstem of normal rat. MATERIAL AND METHODS: Male Sprague-Dawley rats were perfused with 4% paraformaldehyde. Cochleae and brainstems were taken out and processed for surface preparations and frozen sections. Immunoperoxidase immunohistochemistry was carried out using anti-CGRP polyclonal antibody.
RESULTS
Numerous CGRP immunoreactive fibers were located in the inner spiral bundle, intraganglionic nerve fibers, base of inner hair cells and lateral superior olivary nuclei in brainstems.
CONCLUSION
CGRP is one of the neuropeptides in the olivocochlear effent system and may participate in the inhibitory effect on auditory action potential.
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