J Korean Orthop Assoc.  2000 Dec;35(6):833-836.

The Role of Thrombophilia and Hypofibrinolysis in Legg-Calv-Perthes Disease

• Ha YC
• Koo KH
• Park HB
• Cho SW
• Jung YC
• Song HR

Abstract

PURPOSE
The object of present study was to investigate the relationship between LCPD and the abnormality of certain plasma proteins affecting clot mechanism and fibrinolysis in patients with LCP disease.
MATERIALS AND METHODS
Twenty-five consecutive patients who had been diagnosed as LCP disease were matched with twenty-five controls for gender, age (2-year range) , and the time of presentation (1-year range) . There were twenty-three boys and two girls. The mean age of the children when the LCP disease was diagnosed was 6.7 years ( range, 2.1-12.8 years) , and the mean age at the time of the present study was 7.9 years ( range, 3.4 - 13 year) . Thrombotic disorders were investigated for protein C activity/antigenicity, protein S activity/antigenicity, antithrombin III, anticardiolipin antibody Ig G, anticardiolipin antibody Ig M, lupus antibody. Fibrinolytic disorders were investigated for tissue type plasminogen activator (t-PA) , plasminogen, plasminogen activator inhibitor-1 (PAI-1) , alpha 2 plasmin inhibitor, lipoprotein (a) . Wilcoxon rank sum test was used for the comparison.
RESULTS
There was no significant difference in coagulation system and fibrinolytic system between patients and controls.
CONCLUSION
Our results suggest that abnormality in coagulation and fibrinolytic system is not associated with Legg-Calv -Perthes disease.

Keyword

Femoral head; Legg-Calv -Perthes disease; Thrombophilia; Hypofibrinolysis

MeSH Terms

alpha-2-Antiplasmin
Antibodies, Anticardiolipin
Antithrombin III
Blood Proteins
Child
Female
Fibrinolysis
Humans
Lipoprotein(a)
Plasminogen
Plasminogen Activators
Protein C
Protein S
Thrombophilia*
Tissue Plasminogen Activator
Antibodies, Anticardiolipin
Antithrombin III
Blood Proteins
Lipoprotein(a)
Plasminogen
Plasminogen Activators
Protein C
Protein S
Tissue Plasminogen Activator
alpha-2-Antiplasmin